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Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission

Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission
Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission
Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 µA and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply.
1932-6203
1-9
Han, Arum
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Falk, Magnus
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Alcalde, Miguel
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Bartlett, Philip N.
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De Lacey, Antonio L.
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Gorton, Lo
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Gutierrez-Sanchez, Cristina
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Haddad, Raoudha
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Kilburn, Jeremy
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Leech, Dónal
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Ludwig, Roland
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Magner, Edmond
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Mate, Diana M.
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Conghaile, Peter Ó.
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Ortiz, Roberto
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Pita, Marcos
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Pöller, Sascha
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Ruzgas, Tautgirdas
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Salaj-Kosla, Urszula
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Schuhmann, Wolfgang
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Sebelius, Fredrik
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Shao, Minling
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Stoica, Leonard
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Sygmund, Cristoph
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Tilly, Jonas
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Toscano, Miguel D.
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Vivekananthan, Jeevanthi
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Wright, Emma
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Shleev, Sergey
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Han, Arum
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Falk, Magnus
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Alcalde, Miguel
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Bartlett, Philip N.
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De Lacey, Antonio L.
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Gorton, Lo
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Gutierrez-Sanchez, Cristina
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Haddad, Raoudha
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Kilburn, Jeremy
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Leech, Dónal
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Ludwig, Roland
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Magner, Edmond
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Mate, Diana M.
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Conghaile, Peter Ó.
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Ortiz, Roberto
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Pita, Marcos
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Pöller, Sascha
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Ruzgas, Tautgirdas
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Salaj-Kosla, Urszula
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Schuhmann, Wolfgang
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Sebelius, Fredrik
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Shao, Minling
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Stoica, Leonard
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Sygmund, Cristoph
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Tilly, Jonas
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Toscano, Miguel D.
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Vivekananthan, Jeevanthi
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Wright, Emma
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Shleev, Sergey
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Han, Arum, Falk, Magnus and Alcalde, Miguel et al. (2014) Self-powered wireless carbohydrate/oxygen sensitive biodevice based on radio signal transmission. PLoS ONE, 9 (10), 1-9. (doi:10.1371/journal.pone.0109104). (PMID:25310190)

Record type: Article

Abstract

Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 µA and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply.

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Accepted/In Press date: 8 September 2014
Published date: 13 October 2014
Organisations: Chemistry

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Local EPrints ID: 376457
URI: http://eprints.soton.ac.uk/id/eprint/376457
ISSN: 1932-6203
PURE UUID: 3d365624-0158-42bd-bad8-da7aea265a22
ORCID for Philip N. Bartlett: ORCID iD orcid.org/0000-0002-7300-6900

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Date deposited: 28 Apr 2015 14:00
Last modified: 10 Dec 2019 01:56

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Contributors

Author: Arum Han
Author: Magnus Falk
Author: Miguel Alcalde
Author: Antonio L. De Lacey
Author: Lo Gorton
Author: Cristina Gutierrez-Sanchez
Author: Raoudha Haddad
Author: Jeremy Kilburn
Author: Dónal Leech
Author: Roland Ludwig
Author: Edmond Magner
Author: Diana M. Mate
Author: Peter Ó. Conghaile
Author: Roberto Ortiz
Author: Marcos Pita
Author: Sascha Pöller
Author: Tautgirdas Ruzgas
Author: Urszula Salaj-Kosla
Author: Wolfgang Schuhmann
Author: Fredrik Sebelius
Author: Minling Shao
Author: Leonard Stoica
Author: Cristoph Sygmund
Author: Jonas Tilly
Author: Miguel D. Toscano
Author: Jeevanthi Vivekananthan
Author: Emma Wright
Author: Sergey Shleev

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