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Environmental temperature impacts on the performance of QuantiFERON-TB Gold In-Tube assays

Environmental temperature impacts on the performance of QuantiFERON-TB Gold In-Tube assays
Environmental temperature impacts on the performance of QuantiFERON-TB Gold In-Tube assays
We read with interest the recent article by Pan et alwhich highlighted that a substantial proportion of patients with pulmonary and extrapulmonary tuberculosis (TB) have false-negative interferon-gamma release assay (IGRA) results, showing that a negative IGRA result does not rule out active TB. Unfortunately the authors excluded indeterminate assay results from the analyses, despite those results posing a considerable dilemma for clinical management, as they confer no information about the patient's TB infection status
0163-4453
276-280
Jarvis, J.
f0826334-71dc-4dcf-8813-8da7178d4349
Gao, Y.
3f048356-567d-4308-853f-d98fabfcb6fb
de Graaf, Hans
fb174fd4-5130-4a17-88ca-832c150e94e7
Hughes, S.
d246ca0a-9850-46c6-8f64-a11fa8e51085
Allan, R.N.
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1
Williams, A.
973ff46f-46f1-4d7c-b27d-0f53221e4c44
Marshall, B.
c1438a0d-f075-4eb6-806d-7926401fbf00
Elkington, Paul T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a
Jarvis, J.
f0826334-71dc-4dcf-8813-8da7178d4349
Gao, Y.
3f048356-567d-4308-853f-d98fabfcb6fb
de Graaf, Hans
fb174fd4-5130-4a17-88ca-832c150e94e7
Hughes, S.
d246ca0a-9850-46c6-8f64-a11fa8e51085
Allan, R.N.
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1
Williams, A.
973ff46f-46f1-4d7c-b27d-0f53221e4c44
Marshall, B.
c1438a0d-f075-4eb6-806d-7926401fbf00
Elkington, Paul T.
60828c7c-3d32-47c9-9fcc-6c4c54c35a15
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Tebruegge, Marc
2c3dff22-0b5f-48a7-bb36-ce323705f74a

Jarvis, J., Gao, Y., de Graaf, Hans, Hughes, S., Allan, R.N., Williams, A., Marshall, B., Elkington, Paul T., Faust, S.N. and Tebruegge, Marc (2015) Environmental temperature impacts on the performance of QuantiFERON-TB Gold In-Tube assays. Journal of Infection, 71 (2), 276-280. (doi:10.1016/j.inf.2015.04.004). (PMID:25869537)

Record type: Article

Abstract

We read with interest the recent article by Pan et alwhich highlighted that a substantial proportion of patients with pulmonary and extrapulmonary tuberculosis (TB) have false-negative interferon-gamma release assay (IGRA) results, showing that a negative IGRA result does not rule out active TB. Unfortunately the authors excluded indeterminate assay results from the analyses, despite those results posing a considerable dilemma for clinical management, as they confer no information about the patient's TB infection status

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e-pub ahead of print date: 11 April 2015
Published date: August 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 376567
URI: http://eprints.soton.ac.uk/id/eprint/376567
ISSN: 0163-4453
PURE UUID: bc64761f-a280-4a34-a6ad-6455b524b1ac
ORCID for Paul T. Elkington: ORCID iD orcid.org/0000-0003-0390-0613
ORCID for S.N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 01 May 2015 10:55
Last modified: 18 Feb 2021 17:19

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Contributors

Author: J. Jarvis
Author: Y. Gao
Author: Hans de Graaf
Author: S. Hughes
Author: R.N. Allan
Author: A. Williams
Author: B. Marshall
Author: S.N. Faust ORCID iD
Author: Marc Tebruegge

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