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CMOS weak-inversion log-domain glycolytic oscillator: a cytomimetic circuit example

CMOS weak-inversion log-domain glycolytic oscillator: a cytomimetic circuit example
CMOS weak-inversion log-domain glycolytic oscillator: a cytomimetic circuit example
This paper presents a 3?V, 1.21?W subthreshold log-domain circuit which mimics the oscillations observed during the biochemical process of glycolysis due to the phosphofructokinase enzyme. The proposed electronic circuit is able to simulate the dynamics of the glycolytic oscillator and represent the time-dependent concentration changes of the reactants and the products of the chemical process based on nonlinear differential equations which describe the biological system. By modifying specific circuit parameters, which correspond to certain chemical parameters, good agreement between the biochemical and electrical model results has been reached. The paper details the similarities between the equations that describe the biochemical process and the equations derived from the circuit analysis of a transistor and a source-connected linear capacitor, a topology also known as the Bernoulli Cell. With the use of the Bernoulli Cell formalism, the chemical equations which describe the biochemical system have been transformed into their electrical equivalents. The analog circuit, which implements the whole process, has been synthesised, and simulation results including Monte Carlo analysis are provided, in order to verify the robustness of the proposed circuit and to compare its dynamics with prototype biological behaviour
bernoulli cell, cytomimetic, glycolytic oscillator, log-domain circuit, nonlinear, subthreshold MOSFETs
173-194
Papadimitriou, Konstantinos I.
c0535540-f862-41b1-9cf3-92b1f46a4145
Drakakis, Emmanuel M.
e90f288a-ba96-4e6b-af0f-bb7ab850ce99
Papadimitriou, Konstantinos I.
c0535540-f862-41b1-9cf3-92b1f46a4145
Drakakis, Emmanuel M.
e90f288a-ba96-4e6b-af0f-bb7ab850ce99

Papadimitriou, Konstantinos I. and Drakakis, Emmanuel M. (2014) CMOS weak-inversion log-domain glycolytic oscillator: a cytomimetic circuit example. International Journal of Circuit Theory and Applications, 42 (2), 173-194. (doi:10.1002/cta.1847).

Record type: Article

Abstract

This paper presents a 3?V, 1.21?W subthreshold log-domain circuit which mimics the oscillations observed during the biochemical process of glycolysis due to the phosphofructokinase enzyme. The proposed electronic circuit is able to simulate the dynamics of the glycolytic oscillator and represent the time-dependent concentration changes of the reactants and the products of the chemical process based on nonlinear differential equations which describe the biological system. By modifying specific circuit parameters, which correspond to certain chemical parameters, good agreement between the biochemical and electrical model results has been reached. The paper details the similarities between the equations that describe the biochemical process and the equations derived from the circuit analysis of a transistor and a source-connected linear capacitor, a topology also known as the Bernoulli Cell. With the use of the Bernoulli Cell formalism, the chemical equations which describe the biochemical system have been transformed into their electrical equivalents. The analog circuit, which implements the whole process, has been synthesised, and simulation results including Monte Carlo analysis are provided, in order to verify the robustness of the proposed circuit and to compare its dynamics with prototype biological behaviour

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More information

Accepted/In Press date: 31 July 2012
Published date: 17 February 2014
Keywords: bernoulli cell, cytomimetic, glycolytic oscillator, log-domain circuit, nonlinear, subthreshold MOSFETs
Organisations: Bioengineering Group

Identifiers

Local EPrints ID: 376756
URI: http://eprints.soton.ac.uk/id/eprint/376756
PURE UUID: 67a0a042-d71e-4da7-b6c1-1eb67c64295d

Catalogue record

Date deposited: 08 May 2015 12:58
Last modified: 15 Jul 2019 21:21

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