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Squeezing red blood cells on an optical waveguide to monitor cell deformability during blood storage

Squeezing red blood cells on an optical waveguide to monitor cell deformability during blood storage
Squeezing red blood cells on an optical waveguide to monitor cell deformability during blood storage
Red blood cells squeeze through micro-capillaries as part of blood circulation in the body. The deformability of red blood cells is thus critical for blood circulation. In this work, we report a method to optically squeeze red blood cells using the evanescent field present on top of a planar waveguide chip. The optical forces from a narrow waveguide are used to squeeze red blood cells to a size comparable to the waveguide width. Optical forces and pressure distributions on the cells are numerically computed to explain the squeezing process. The proposed technique is used to quantify the loss of blood deformability that occurs during blood storage lesion. Squeezing red blood cells using waveguides is a sensitive technique and works simultaneously on several cells, making the method suitable for monitoring stored blood.
0003-2654
223-229
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0
McCourt, Peter
5786a794-fbdb-4215-afae-d558d98bf60c
Oteiza, Ana
5d12e43c-ad8e-4e1e-a74a-607a0c3183b2
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Huser, Thomas R.
f1aa9651-07f8-423b-8e96-05b45bbdee83
Hellesø, Olav Gaute
7c341b6b-c11d-475d-aedd-558f02210e53
Ahluwalia, Balpreet Singh
f6dfb1bb-760f-4a7e-9050-d66de72348e0
McCourt, Peter
5786a794-fbdb-4215-afae-d558d98bf60c
Oteiza, Ana
5d12e43c-ad8e-4e1e-a74a-607a0c3183b2
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Huser, Thomas R.
f1aa9651-07f8-423b-8e96-05b45bbdee83
Hellesø, Olav Gaute
7c341b6b-c11d-475d-aedd-558f02210e53

Ahluwalia, Balpreet Singh, McCourt, Peter, Oteiza, Ana, Wilkinson, James S., Huser, Thomas R. and Hellesø, Olav Gaute (2015) Squeezing red blood cells on an optical waveguide to monitor cell deformability during blood storage. Analyst, 140 (1), 223-229. (doi:10.1039/c4an01181c).

Record type: Article

Abstract

Red blood cells squeeze through micro-capillaries as part of blood circulation in the body. The deformability of red blood cells is thus critical for blood circulation. In this work, we report a method to optically squeeze red blood cells using the evanescent field present on top of a planar waveguide chip. The optical forces from a narrow waveguide are used to squeeze red blood cells to a size comparable to the waveguide width. Optical forces and pressure distributions on the cells are numerically computed to explain the squeezing process. The proposed technique is used to quantify the loss of blood deformability that occurs during blood storage lesion. Squeezing red blood cells using waveguides is a sensitive technique and works simultaneously on several cells, making the method suitable for monitoring stored blood.

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More information

e-pub ahead of print date: 23 October 2014
Published date: 7 January 2015
Organisations: Optoelectronics Research Centre

Identifiers

Local EPrints ID: 376916
URI: https://eprints.soton.ac.uk/id/eprint/376916
ISSN: 0003-2654
PURE UUID: b9db3a5e-47d1-423a-84bb-c472dcc36f2e
ORCID for James S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697

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Date deposited: 11 May 2015 10:41
Last modified: 19 Jul 2019 01:25

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