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Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice

Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice
Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice
Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX® algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g. diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX.
osteoporosis, epidemiology, trabecular bone score (TBS), fragility fracture, bone mineral density, FRAX
8756-3282
216-224
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Glüer, C.C.
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Binkley, N.
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McCloskey, E.V.
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Brandi, M.-L.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Kendler, D.
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Lamy, O.
dea1c9d3-620e-486f-8f03-303466240dd5
Laslop, A.
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Camargos, B.M.
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Reginster, J.-Y.
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Rizzoli, R.
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Kanis, J.A.
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Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Glüer, C.C.
26bce742-ab40-46b5-83cd-58940f016e64
Binkley, N.
db1bbdc5-b719-4bbd-b0e3-a0bf2a804319
McCloskey, E.V.
38518227-db8f-4a53-88a6-462f469151de
Brandi, M.-L.
0d391b6d-6266-4e57-833d-ced07819eb3a
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Kendler, D.
0fad1009-867f-435d-a534-4c9c89152854
Lamy, O.
dea1c9d3-620e-486f-8f03-303466240dd5
Laslop, A.
ca0887e1-5fce-4ac3-bbaf-f2aa98be3e0f
Camargos, B.M.
c7d472e1-816d-4f1d-9df2-7b7e18a2fff7
Reginster, J.-Y.
8b548609-99db-46ae-a28a-7967ba8c7483
Rizzoli, R.
2214fb77-8fb7-4c0b-bfc4-9f8d3cace5d7
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587

Harvey, N.C., Glüer, C.C., Binkley, N., McCloskey, E.V., Brandi, M.-L., Cooper, C., Kendler, D., Lamy, O., Laslop, A., Camargos, B.M., Reginster, J.-Y., Rizzoli, R. and Kanis, J.A. (2015) Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice. Bone, 78, 216-224. (doi:10.1016/j.bone.2015.05.016). (PMID:25988660)

Record type: Article

Abstract

Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX® algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g. diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX.

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More information

Accepted/In Press date: 12 May 2015
e-pub ahead of print date: 16 May 2015
Published date: September 2015
Keywords: osteoporosis, epidemiology, trabecular bone score (TBS), fragility fracture, bone mineral density, FRAX
Organisations: NIHR Southampton Biomedical Research Centre, MRC Life-Course Epidemiology Unit

Identifiers

Local EPrints ID: 377245
URI: http://eprints.soton.ac.uk/id/eprint/377245
ISSN: 8756-3282
PURE UUID: cf8c842d-73c5-4830-af80-21e4c7bea154
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 27 May 2015 13:56
Last modified: 18 Mar 2024 02:58

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Contributors

Author: N.C. Harvey ORCID iD
Author: C.C. Glüer
Author: N. Binkley
Author: E.V. McCloskey
Author: M.-L. Brandi
Author: C. Cooper ORCID iD
Author: D. Kendler
Author: O. Lamy
Author: A. Laslop
Author: B.M. Camargos
Author: J.-Y. Reginster
Author: R. Rizzoli
Author: J.A. Kanis

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