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Neuroinflammation in Alzheimer's disease

Neuroinflammation in Alzheimer's disease
Neuroinflammation in Alzheimer's disease
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease
1474-4465
388-405
Heneka, Michael
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Carson, Monica
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El Khoury, Joseph
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Landreth, Gary
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Brosseron, Frederic
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Feinstein, Douglas
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Jacobs, Andreas
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Wyss-Coray, Tony
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Vitorica, Javier
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Ransohoff, Richard
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Herrup, Karl
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Frautschy, Sally
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Finsen, Bente
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Brown, Guy
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Verkhratsky, Alexei
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Yamanaka, Koji
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Koistinaho, Jari
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Latz, Eicke
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Halle, Annett
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Petzold, Gabor C.
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Town, Terrence
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Morgan, Dave
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Shinohara, Mari L.
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Perry, V Hugh
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Holmes, Clive
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Bazan, Nicolas G.
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Brooks, David J.
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Hunot, Stéphane
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Joseph, Bertrand
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Deigendesch, Nikolaus
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Garaschuk, Olga
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Boddeke, Erik
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Dinarello, Charles A.
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Breitner, John C.
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Cole, Greg M.
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Golenbock, Douglas T.
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Kummer, Markus P.
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Heneka, Michael
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Carson, Monica
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El Khoury, Joseph
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Landreth, Gary
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Brosseron, Frederic
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Feinstein, Douglas
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Jacobs, Andreas
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Wyss-Coray, Tony
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Vitorica, Javier
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Ransohoff, Richard
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Herrup, Karl
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Frautschy, Sally
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Finsen, Bente
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Brown, Guy
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Verkhratsky, Alexei
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Yamanaka, Koji
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Koistinaho, Jari
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Halle, Annett
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Petzold, Gabor C.
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Town, Terrence
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Morgan, Dave
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Shinohara, Mari L.
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Perry, V Hugh
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Holmes, Clive
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Bazan, Nicolas G.
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Brooks, David J.
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Hunot, Stéphane
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Joseph, Bertrand
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Deigendesch, Nikolaus
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Garaschuk, Olga
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Boddeke, Erik
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Dinarello, Charles A.
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Breitner, John C.
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Cole, Greg M.
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Golenbock, Douglas T.
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Kummer, Markus P.
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Heneka, Michael, Carson, Monica, El Khoury, Joseph, Landreth, Gary, Brosseron, Frederic, Feinstein, Douglas, Jacobs, Andreas, Wyss-Coray, Tony, Vitorica, Javier, Ransohoff, Richard, Herrup, Karl, Frautschy, Sally, Finsen, Bente, Brown, Guy, Verkhratsky, Alexei, Yamanaka, Koji, Koistinaho, Jari, Latz, Eicke, Halle, Annett, Petzold, Gabor C., Town, Terrence, Morgan, Dave, Shinohara, Mari L., Perry, V Hugh, Holmes, Clive, Bazan, Nicolas G., Brooks, David J., Hunot, Stéphane, Joseph, Bertrand, Deigendesch, Nikolaus, Garaschuk, Olga, Boddeke, Erik, Dinarello, Charles A., Breitner, John C., Cole, Greg M., Golenbock, Douglas T. and Kummer, Markus P. (2015) Neuroinflammation in Alzheimer's disease. The Lancet Neurology, 14 (4), 388-405. (doi:10.1016/S1474-4422(15)70016-5). (PMID:25792098)

Record type: Article

Abstract

Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release of inflammatory mediators, which contribute to disease progression and severity. Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction. External factors, including systemic inflammation and obesity, are likely to interfere with immunological processes of the brain and further promote disease progression. Modulation of risk factors and targeting of these immune mechanisms could lead to future therapeutic or preventive strategies for Alzheimer's disease

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Published date: 14 April 2015
Organisations: Biomedicine, Centre for Biological Sciences

Identifiers

Local EPrints ID: 377368
URI: https://eprints.soton.ac.uk/id/eprint/377368
ISSN: 1474-4465
PURE UUID: 850ccd9e-590e-4567-9034-4b24a0b20451

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Date deposited: 29 May 2015 13:28
Last modified: 16 Sep 2019 18:28

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Contributors

Author: Michael Heneka
Author: Monica Carson
Author: Joseph El Khoury
Author: Gary Landreth
Author: Frederic Brosseron
Author: Douglas Feinstein
Author: Andreas Jacobs
Author: Tony Wyss-Coray
Author: Javier Vitorica
Author: Richard Ransohoff
Author: Karl Herrup
Author: Sally Frautschy
Author: Bente Finsen
Author: Guy Brown
Author: Alexei Verkhratsky
Author: Koji Yamanaka
Author: Jari Koistinaho
Author: Eicke Latz
Author: Annett Halle
Author: Gabor C. Petzold
Author: Terrence Town
Author: Dave Morgan
Author: Mari L. Shinohara
Author: V Hugh Perry
Author: Clive Holmes
Author: Nicolas G. Bazan
Author: David J. Brooks
Author: Stéphane Hunot
Author: Bertrand Joseph
Author: Nikolaus Deigendesch
Author: Olga Garaschuk
Author: Erik Boddeke
Author: Charles A. Dinarello
Author: John C. Breitner
Author: Greg M. Cole
Author: Douglas T. Golenbock
Author: Markus P. Kummer

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