Full-field in vitro measurements and in silico predictions of strain shielding in the implanted femur after total hip arthroplasty
Full-field in vitro measurements and in silico predictions of strain shielding in the implanted femur after total hip arthroplasty
Alterations in bone strain as a result of implantation may contribute towards periprosthetic bone density changes after Total Hip Arthroplasty (THA). Computational models provide full-field strain predictions in implant-bone constructs; however, these predictions should be verified using experimental models wherever possible. In the present work, finite element (FE) predictions of surface strains in intact and implanted composite femurs were verified using digital image correlation (DIC). Relationships were sought between post implantation strain states across seven defined Gruen zones (GZ) and clinically observed longer- term bone density changes. Computational predictions of strain distributions in intact and implanted femurs were compared to DIC measurements in two regions of interest. Regression analyses indicated a strong linear correlation between measurements and predictions (R = 0.927 intact, 0.926 implanted) with low standard error (SE = 38µ? intact, 26µ? implanted). Pre- to postoperative changes in measured and predicted surface strains were found to relate qualitatively to clinically-observed volumetric bone density changes across seven Gruen zones: marked proximal bone density loss corresponded with a 50-64% drop in surface strain, and slight distal density changes corresponded with 4-14% strain increase. These results support the use of DIC as a pre-clinical tool for predicting post implantation strain shielding, indicative of long-term bone adaptations.
total hip arthroplasty, bone adaptation, mechanical testing, digital image correlation, finite element analysis
549-559
Chanda, S.
097a8af6-a244-4db7-9ffc-cd623c24eab8
Dickinson, A.S.
10151972-c1b5-4f7d-bc12-6482b5870cad
Gupta, S.
3eae7ae7-8915-4c1f-8f28-2882160b9a62
Browne, M.
6578cc37-7bd6-43b9-ae5c-77ccb7726397
3 August 2015
Chanda, S.
097a8af6-a244-4db7-9ffc-cd623c24eab8
Dickinson, A.S.
10151972-c1b5-4f7d-bc12-6482b5870cad
Gupta, S.
3eae7ae7-8915-4c1f-8f28-2882160b9a62
Browne, M.
6578cc37-7bd6-43b9-ae5c-77ccb7726397
Chanda, S., Dickinson, A.S., Gupta, S. and Browne, M.
(2015)
Full-field in vitro measurements and in silico predictions of strain shielding in the implanted femur after total hip arthroplasty.
Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 229 (8), .
(doi:10.1177/0954411915591617).
(PMID:26112349)
Abstract
Alterations in bone strain as a result of implantation may contribute towards periprosthetic bone density changes after Total Hip Arthroplasty (THA). Computational models provide full-field strain predictions in implant-bone constructs; however, these predictions should be verified using experimental models wherever possible. In the present work, finite element (FE) predictions of surface strains in intact and implanted composite femurs were verified using digital image correlation (DIC). Relationships were sought between post implantation strain states across seven defined Gruen zones (GZ) and clinically observed longer- term bone density changes. Computational predictions of strain distributions in intact and implanted femurs were compared to DIC measurements in two regions of interest. Regression analyses indicated a strong linear correlation between measurements and predictions (R = 0.927 intact, 0.926 implanted) with low standard error (SE = 38µ? intact, 26µ? implanted). Pre- to postoperative changes in measured and predicted surface strains were found to relate qualitatively to clinically-observed volumetric bone density changes across seven Gruen zones: marked proximal bone density loss corresponded with a 50-64% drop in surface strain, and slight distal density changes corresponded with 4-14% strain increase. These results support the use of DIC as a pre-clinical tool for predicting post implantation strain shielding, indicative of long-term bone adaptations.
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Chanda PP 2015.pdf
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More information
Accepted/In Press date: 19 May 2015
e-pub ahead of print date: 25 June 2015
Published date: 3 August 2015
Keywords:
total hip arthroplasty, bone adaptation, mechanical testing, digital image correlation, finite element analysis
Organisations:
Bioengineering Group
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Local EPrints ID: 377466
URI: http://eprints.soton.ac.uk/id/eprint/377466
ISSN: 0954-4119
PURE UUID: 6f8b9e49-1159-4852-b9fe-cbb6c2a6c642
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Date deposited: 15 Jun 2015 10:15
Last modified: 15 Mar 2024 03:27
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Author:
S. Chanda
Author:
S. Gupta
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