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Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)

Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)
Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF)
Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands
117
Brenna, J.
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Akomo, P.
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Bahwere, P.
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Berkley, J.
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Calder, P.C.
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Jones, K.
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Liu, L.
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Manary, M.
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Trehan, I.
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Briend, A.
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Brenna, J.
23692f96-d758-42f3-8ad3-c49037a0ef7e
Akomo, P.
e1df41cd-32d5-46a0-b7aa-383ee16019b9
Bahwere, P.
5ca80883-f281-4ee9-99a6-d0262f394888
Berkley, J.
d01e45d6-e6d7-4e64-86be-12ffced7841b
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Jones, K.
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Liu, L.
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Manary, M.
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Trehan, I.
bbc7f94e-6980-4488-93df-65ef23a9b392
Briend, A.
cf090233-a6cd-418b-84a8-695e16fc59be

Brenna, J., Akomo, P., Bahwere, P., Berkley, J., Calder, P.C., Jones, K., Liu, L., Manary, M., Trehan, I. and Briend, A. (2015) Balancing omega-6 and omega-3 fatty acids in ready-to-use therapeutic foods (RUTF). BMC Medicine, 13 (1), 117. (doi:10.1186/s12916-015-0352-1). (PMID:25980919)

Record type: Article

Abstract

Ready-to-use therapeutic foods (RUTFs) are a key component of a life-saving treatment for young children who present with uncomplicated severe acute malnutrition in resource limited settings. Increasing recognition of the role of balanced dietary omega-6 and omega-3 polyunsaturated fatty acids (PUFA) in neurocognitive and immune development led two independent groups to evaluate RUTFs. Jones et al. (BMC Med 13:93, 2015), in a study in BMC Medicine, and Hsieh et al. (J Pediatr Gastroenterol Nutr 2015), in a study in the Journal of Pediatric Gastroenterology and Nutrition, reformulated RUTFs with altered PUFA content and looked at the effects on circulating omega-3 docosahexaenoic acid (DHA) status as a measure of overall omega-3 status. Supplemental oral administration of omega-3 DHA or reduction of RUTF omega-6 linoleic acid using high oleic peanuts improved DHA status, whereas increasing omega-3 alpha-linolenic acid in RUTF did not. The results of these two small studies are consistent with well-established effects in animal studies and highlight the need for basic and operational research to improve fat composition in support of omega-3-specific development in young children as RUTF use expands

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Published date: 15 May 2015
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 377590
URI: http://eprints.soton.ac.uk/id/eprint/377590
PURE UUID: 78e20ff4-0431-4a1b-80be-bee8074e9ab1

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Date deposited: 12 Jun 2015 11:04
Last modified: 16 Dec 2019 20:17

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Contributors

Author: J. Brenna
Author: P. Akomo
Author: P. Bahwere
Author: J. Berkley
Author: P.C. Calder
Author: K. Jones
Author: L. Liu
Author: M. Manary
Author: I. Trehan
Author: A. Briend

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