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Inflammation and nutritional science for programs/policies and interpretation of research evidence (INSPIRE)

Inflammation and nutritional science for programs/policies and interpretation of research evidence (INSPIRE)
Inflammation and nutritional science for programs/policies and interpretation of research evidence (INSPIRE)
An increasing recognition has emerged of the complexities of the global health agenda-specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers. The goal of the Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) is to provide guidance for those users represented by the global food and nutrition enterprise. These include researchers (bench and clinical), clinicians providing care/treatment, those developing and evaluating programs/interventions at scale, and those responsible for generating evidence-based policy. The INSPIRE process included convening 5 thematic working groups (WGs) charged with developing summary reports around the following issues: 1) basic overview of the interactions between nutrition, immune function, and the inflammatory response; 2) examination of the evidence regarding the impact of nutrition on immune function and inflammation; 3) evaluation of the impact of inflammation and clinical conditions (acute and chronic) on nutrition; 4) examination of existing and potential new approaches to account for the impact of inflammation on biomarker interpretation and use; and 5) the presentation of new approaches to the study of these relations. Each WG was tasked with synthesizing a summary of the evidence for each of these topics and delineating the remaining gaps in our knowledge. This review consists of a summary of the INSPIRE workshop and the WG deliberations
BOND and inflammation/infection, assessment of micronutrient biomarkers, immune function and nutrients, inflammation and nutrition, nutrition biomarkers
0022-3166
1039S-1108S
Raiten, D.
c97532b7-a866-40b3-8de9-196c2ba2d0cd
Ashour, F.
a57e4925-c0fe-4180-9818-93ec1b50a885
Ross, A.
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Meydani, S.
64319443-405a-4673-aa4a-45916a7f4aef
Dawson, H.
473a3c14-5dbc-4b4f-9fab-a24a20d4a7fb
Stephensen, C.
387618e7-8dcc-4685-ad4c-1bb299f72a1b
Brabin, B.
a0d3cb5a-79fc-4700-a999-285db20413c2
Suchdev, P.
e9c93325-a025-4879-b393-a6cb198ad8f8
van Ommen, B.
fbcb5330-238a-4a3d-9ec3-f6c6a232c5be
Calder, P.C.
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Raiten, D.
c97532b7-a866-40b3-8de9-196c2ba2d0cd
Ashour, F.
a57e4925-c0fe-4180-9818-93ec1b50a885
Ross, A.
31d232df-e682-4729-b7d3-af01277fed01
Meydani, S.
64319443-405a-4673-aa4a-45916a7f4aef
Dawson, H.
473a3c14-5dbc-4b4f-9fab-a24a20d4a7fb
Stephensen, C.
387618e7-8dcc-4685-ad4c-1bb299f72a1b
Brabin, B.
a0d3cb5a-79fc-4700-a999-285db20413c2
Suchdev, P.
e9c93325-a025-4879-b393-a6cb198ad8f8
van Ommen, B.
fbcb5330-238a-4a3d-9ec3-f6c6a232c5be
Calder, P.C.
1797e54f-378e-4dcb-80a4-3e30018f07a6

Raiten, D., Ashour, F., Ross, A., Meydani, S., Dawson, H., Stephensen, C., Brabin, B., Suchdev, P., van Ommen, B. and Calder, P.C. (2015) Inflammation and nutritional science for programs/policies and interpretation of research evidence (INSPIRE). Journal of Nutrition, 145 (5), 1039S-1108S. (doi:10.3945/jn.114.194571). (PMID:25833893)

Record type: Review

Abstract

An increasing recognition has emerged of the complexities of the global health agenda-specifically, the collision of infections and noncommunicable diseases and the dual burden of over- and undernutrition. Of particular practical concern are both 1) the need for a better understanding of the bidirectional relations between nutritional status and the development and function of the immune and inflammatory response and 2) the specific impact of the inflammatory response on the selection, use, and interpretation of nutrient biomarkers. The goal of the Inflammation and Nutritional Science for Programs/Policies and Interpretation of Research Evidence (INSPIRE) is to provide guidance for those users represented by the global food and nutrition enterprise. These include researchers (bench and clinical), clinicians providing care/treatment, those developing and evaluating programs/interventions at scale, and those responsible for generating evidence-based policy. The INSPIRE process included convening 5 thematic working groups (WGs) charged with developing summary reports around the following issues: 1) basic overview of the interactions between nutrition, immune function, and the inflammatory response; 2) examination of the evidence regarding the impact of nutrition on immune function and inflammation; 3) evaluation of the impact of inflammation and clinical conditions (acute and chronic) on nutrition; 4) examination of existing and potential new approaches to account for the impact of inflammation on biomarker interpretation and use; and 5) the presentation of new approaches to the study of these relations. Each WG was tasked with synthesizing a summary of the evidence for each of these topics and delineating the remaining gaps in our knowledge. This review consists of a summary of the INSPIRE workshop and the WG deliberations

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Accepted/In Press date: 29 October 2014
e-pub ahead of print date: 1 April 2015
Published date: May 2015
Keywords: BOND and inflammation/infection, assessment of micronutrient biomarkers, immune function and nutrients, inflammation and nutrition, nutrition biomarkers
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 377592
URI: http://eprints.soton.ac.uk/id/eprint/377592
ISSN: 0022-3166
PURE UUID: dde2d040-8149-4c2c-9048-b119efea5f57
ORCID for P.C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 16 Jun 2015 13:00
Last modified: 15 Mar 2024 02:50

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Contributors

Author: D. Raiten
Author: F. Ashour
Author: A. Ross
Author: S. Meydani
Author: H. Dawson
Author: C. Stephensen
Author: B. Brabin
Author: P. Suchdev
Author: B. van Ommen
Author: P.C. Calder ORCID iD

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