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Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP Study)

Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP Study)
Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP Study)
Background: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.

Objective: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).

Methods: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.

Results: Iron depletion (ferritin <15 ?g/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 ?g/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ?20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).

Conclusion: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV.
vascular stiffness, iron, pregnancy, infant, micronutrients, anaemia
1661-7800
297-303
Alwan, Nisreen A.
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Cade, Janet E.
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McArdle, Harry J.
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Greenwood, Darren C.
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Hayes, Helen E.
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Ciantar, Etienne
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Simpson, Nigel A.B.
f720159e-5eff-4cdd-a315-048079c683af
Alwan, Nisreen A.
0d37b320-f325-4ed3-ba51-0fe2866d5382
Cade, Janet E.
8c643623-de48-455e-bec4-dd317207290a
McArdle, Harry J.
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Greenwood, Darren C.
eb1a8eca-2608-4cd6-baeb-e2ecf8b4cf50
Hayes, Helen E.
ccd2f5d8-f5cb-4150-92d7-e1dff8ff1668
Ciantar, Etienne
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Simpson, Nigel A.B.
f720159e-5eff-4cdd-a315-048079c683af

Alwan, Nisreen A., Cade, Janet E., McArdle, Harry J., Greenwood, Darren C., Hayes, Helen E., Ciantar, Etienne and Simpson, Nigel A.B. (2015) Infant arterial stiffness and maternal iron status in pregnancy: a UK birth cohort (Baby VIP Study). Neonatology, 107 (4), 297-303. (doi:10.1159/000377618). (PMID:25790854)

Record type: Article

Abstract

Background: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status.

Objective: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV).

Methods: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2-6 weeks.

Results: Iron depletion (ferritin <15 ?g/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 ?g/l = 0.02, 95% CI: -0.01, 0.1), nor with iron depletion (adjusted change = -0.2, 95% CI: -0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at ?20 weeks' gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9).

Conclusion: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV.

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Published date: 12 March 2015
Keywords: vascular stiffness, iron, pregnancy, infant, micronutrients, anaemia
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 377639
URI: https://eprints.soton.ac.uk/id/eprint/377639
ISSN: 1661-7800
PURE UUID: 0ce8e5d9-f36d-4db4-88af-caafbbc3f2a0
ORCID for Nisreen A. Alwan: ORCID iD orcid.org/0000-0002-4134-8463

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Date deposited: 03 Jun 2015 10:25
Last modified: 20 Jul 2019 00:34

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