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Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at Age 10: findings from the Avon Longitudinal Study of Parents and Children

Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at Age 10: findings from the Avon Longitudinal Study of Parents and Children
Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at Age 10: findings from the Avon Longitudinal Study of Parents and Children
Background: iron deficiency is common during pregnancy. Experimental animal studies suggest that it increases cardiovascular risk in the offspring.

Objective: to examine the relationship between maternal pregnancy dietary and supplement iron intake and hemoglobin, with offspring’s arterial stiffness (measured by carotid-radial pulse wave velocity), endothelial function (measured by brachial artery flow mediated dilatation), blood pressure, and adiposity (measured by body mass index), test for mediation by cord ferritin, birth weight, gestational age, and child dietary iron intake, and for effect modification by maternal vitamin C intake and offspring sex.

Design: prospective data from 2958 mothers and children pairs at 10 years of age enrolled in an English birth cohort, the Avon Longitudinal Study for Parents and Children (ALSPAC), was analysed.

Results: 2639 (89.2%) mothers reported dietary iron intake in pregnancy below the UK reference nutrient intake of 14.8 mg/day. 1328 (44.9%) reported taking iron supplements, and 129 (4.4%) were anemic by 18 weeks gestation. No associations were observed apart from maternal iron intake from supplements with offspring systolic blood pressure (?0.8 mmHg, 99% CI ?1.7 to 0, P = 0.01 in the sample with all relevant data observed, and ?0.7 mmHg, 99% CI ?1.3 to 0, P = 0.008 in the sample with missing data imputed).

Conclusion: there was no evidence of association between maternal pregnancy dietary iron intake, or maternal hemoglobin concentration (which is less likely to be biased by subjective reporting) with offspring outcomes. There was a modest inverse association between maternal iron supplement intake during pregnancy with offspring systolic blood pressure at 10 years
1932-6203
e84684
Alwan, Nisreen A.
0d37b320-f325-4ed3-ba51-0fe2866d5382
Cade, Janet E.
8c643623-de48-455e-bec4-dd317207290a
Greenwood, Darren C.
eb1a8eca-2608-4cd6-baeb-e2ecf8b4cf50
Deanfield, John
3ffa04cf-a239-4dd7-8d77-dfc9cfe716fd
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4
Alwan, Nisreen A.
0d37b320-f325-4ed3-ba51-0fe2866d5382
Cade, Janet E.
8c643623-de48-455e-bec4-dd317207290a
Greenwood, Darren C.
eb1a8eca-2608-4cd6-baeb-e2ecf8b4cf50
Deanfield, John
3ffa04cf-a239-4dd7-8d77-dfc9cfe716fd
Lawlor, Debbie A.
799826df-f115-4fb7-83ea-53c246c220d4

Alwan, Nisreen A., Cade, Janet E., Greenwood, Darren C., Deanfield, John and Lawlor, Debbie A. (2014) Associations of maternal iron intake and hemoglobin in pregnancy with offspring vascular phenotypes and adiposity at Age 10: findings from the Avon Longitudinal Study of Parents and Children. PLoS ONE, 9 (1), e84684. (doi:10.1371/journal.pone.0084684).

Record type: Article

Abstract

Background: iron deficiency is common during pregnancy. Experimental animal studies suggest that it increases cardiovascular risk in the offspring.

Objective: to examine the relationship between maternal pregnancy dietary and supplement iron intake and hemoglobin, with offspring’s arterial stiffness (measured by carotid-radial pulse wave velocity), endothelial function (measured by brachial artery flow mediated dilatation), blood pressure, and adiposity (measured by body mass index), test for mediation by cord ferritin, birth weight, gestational age, and child dietary iron intake, and for effect modification by maternal vitamin C intake and offspring sex.

Design: prospective data from 2958 mothers and children pairs at 10 years of age enrolled in an English birth cohort, the Avon Longitudinal Study for Parents and Children (ALSPAC), was analysed.

Results: 2639 (89.2%) mothers reported dietary iron intake in pregnancy below the UK reference nutrient intake of 14.8 mg/day. 1328 (44.9%) reported taking iron supplements, and 129 (4.4%) were anemic by 18 weeks gestation. No associations were observed apart from maternal iron intake from supplements with offspring systolic blood pressure (?0.8 mmHg, 99% CI ?1.7 to 0, P = 0.01 in the sample with all relevant data observed, and ?0.7 mmHg, 99% CI ?1.3 to 0, P = 0.008 in the sample with missing data imputed).

Conclusion: there was no evidence of association between maternal pregnancy dietary iron intake, or maternal hemoglobin concentration (which is less likely to be biased by subjective reporting) with offspring outcomes. There was a modest inverse association between maternal iron supplement intake during pregnancy with offspring systolic blood pressure at 10 years

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Accepted/In Press date: 18 November 2013
e-pub ahead of print date: 6 January 2014
Published date: 6 January 2014
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 377781
URI: https://eprints.soton.ac.uk/id/eprint/377781
ISSN: 1932-6203
PURE UUID: 84127062-cac6-41e0-83cc-eb2f1f72024c
ORCID for Nisreen A. Alwan: ORCID iD orcid.org/0000-0002-4134-8463

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Date deposited: 05 Jun 2015 10:36
Last modified: 01 Oct 2019 00:33

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Contributors

Author: Janet E. Cade
Author: Darren C. Greenwood
Author: John Deanfield
Author: Debbie A. Lawlor

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