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Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction?

Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction?
Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction?
The aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a) fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction. A cohort of 2,643 pregnant women, aged 18–45 years, attending two UK maternity units between 8 and 12 weeks gestation, was recruited. A validated tool assessed caffeine intake at different stages of pregnancy and caffeine metabolism was assessed from a caffeine challenge test. Experience of nausea and vomiting of pregnancy was self-reported for each trimester. Adjustment was made for confounders, including salivary cotinine as a biomarker of current smoking status. There were no significant associations between fetal growth restriction and nausea and vomiting in pregnancy, even after adjustment for smoking and alcohol intake. There were no significant differences in the relationship between caffeine intake and fetal growth restriction between those experiencing symptoms of nausea and vomiting and those who did not, for either the first (p = 0.50) or second trimester (p = 0.61) after adjustment for smoking, alcohol intake and caffeine half-life. There were also no significant differences in the relationship between caffeine half-life and fetal growth restriction between those experiencing symptoms of nausea and vomiting and those who did not, for either the first trimester (p = 0.91) or the second trimester (p = 0.45) after adjusting for smoking, alcohol intake and caffeine intake. The results from this study show no evidence that the relationship between maternal caffeine intake and fetal growth restriction is modified by nausea and vomiting in pregnancy
1092-7875
601-608
Boylan, S.M.
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Greenwood, D.C.
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Alwan, N.
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Cooke, M.S.
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Dolby, V.A.
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Hay, A.W.M.
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Kirk, S.F.L.
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Konje, J.C.
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Potdar, N.
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Shires, S.
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Simpson, N.A.B.
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Taub, N.
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Thomas, J.D.
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Walker, J.J.
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White, K.L.M.
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Wild, C.P.
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Cade, J.E.
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Boylan, S.M.
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Greenwood, D.C.
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Alwan, N.
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Cooke, M.S.
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Dolby, V.A.
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Hay, A.W.M.
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Kirk, S.F.L.
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Konje, J.C.
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Potdar, N.
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Shires, S.
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Simpson, N.A.B.
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Taub, N.
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Thomas, J.D.
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Walker, J.J.
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White, K.L.M.
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Wild, C.P.
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Cade, J.E.
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Boylan, S.M., Greenwood, D.C., Alwan, N., Cooke, M.S., Dolby, V.A., Hay, A.W.M., Kirk, S.F.L., Konje, J.C., Potdar, N., Shires, S., Simpson, N.A.B., Taub, N., Thomas, J.D., Walker, J.J., White, K.L.M., Wild, C.P. and Cade, J.E. (2012) Does nausea and vomiting of pregnancy play a role in the association found between maternal caffeine intake and fetal growth restriction? Maternal and Child Health Journal, 17 (4), 601-608. (doi:10.1007/s10995-012-1034-7). (PMID:22644451)

Record type: Article

Abstract

The aim of this study was to explore the relationships between nausea and vomiting in pregnancy and (a) fetal growth restriction; and (b) maternal caffeine metabolism and fetal growth restriction. A cohort of 2,643 pregnant women, aged 18–45 years, attending two UK maternity units between 8 and 12 weeks gestation, was recruited. A validated tool assessed caffeine intake at different stages of pregnancy and caffeine metabolism was assessed from a caffeine challenge test. Experience of nausea and vomiting of pregnancy was self-reported for each trimester. Adjustment was made for confounders, including salivary cotinine as a biomarker of current smoking status. There were no significant associations between fetal growth restriction and nausea and vomiting in pregnancy, even after adjustment for smoking and alcohol intake. There were no significant differences in the relationship between caffeine intake and fetal growth restriction between those experiencing symptoms of nausea and vomiting and those who did not, for either the first (p = 0.50) or second trimester (p = 0.61) after adjustment for smoking, alcohol intake and caffeine half-life. There were also no significant differences in the relationship between caffeine half-life and fetal growth restriction between those experiencing symptoms of nausea and vomiting and those who did not, for either the first trimester (p = 0.91) or the second trimester (p = 0.45) after adjusting for smoking, alcohol intake and caffeine intake. The results from this study show no evidence that the relationship between maternal caffeine intake and fetal growth restriction is modified by nausea and vomiting in pregnancy

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Published date: 29 May 2012
Organisations: Primary Care & Population Sciences

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Local EPrints ID: 377782
URI: https://eprints.soton.ac.uk/id/eprint/377782
ISSN: 1092-7875
PURE UUID: 28939e1d-ad79-4d9e-88e0-61b8554b0a10
ORCID for N. Alwan: ORCID iD orcid.org/0000-0002-4134-8463

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Date deposited: 05 Jun 2015 10:48
Last modified: 20 Jul 2019 00:34

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Contributors

Author: S.M. Boylan
Author: D.C. Greenwood
Author: N. Alwan ORCID iD
Author: M.S. Cooke
Author: V.A. Dolby
Author: A.W.M. Hay
Author: S.F.L. Kirk
Author: J.C. Konje
Author: N. Potdar
Author: S. Shires
Author: N.A.B. Simpson
Author: N. Taub
Author: J.D. Thomas
Author: J.J. Walker
Author: K.L.M. White
Author: C.P. Wild
Author: J.E. Cade

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