The University of Southampton
University of Southampton Institutional Repository

Traffic of antigen presenting cells to and from the brain

Record type: Article

In the normal healthy rodent brain, there are no dendritic cells. However, following acute brain injury, and in immune mediated lesions, small numbers of OX62+ve dendritic cells appear in the rat brain parenchyma. To investigate the origin of these cells, rats with acute excitotoxic lesions were subjected to a number of different manipulations. Depletion of the ED2+
perivascular macrophages by intracerebroventricular injection of chlodronate liposomes did not prevent the appearance of OX62+ve cells in the parenchyma, but bone marrow depletion by whole body irradiation abrogated their appearance. Thus, the OX62+ve cells are derived from blood and not transformation of resident cell populations. To investigate whether potential antigen presenting cells in the brain parenchyma, such as
the perivascular cells, traffic from brain to the peripheral immune system fluorescent microspheres approximating the size of a virus (0.02 micrometre) or a bacterium (1.00 micrometre) were microinjected into distinct brain compartments. Injection into the meninges or ventricles led to the appearance of the fluorescent microspheres in the cervical lymph nodes and the liver. In contrast no fluorescent microspheres were found peripherally following injections restricted to the parenchyma. The microspheres were
observed within perivascular macrophages. A local inflammatory response within the brain resulted in a dramatic alteration of the distribution of microspheres delivered to the parenchyma.

Full text not available from this repository.

Citation

Newman, T., Carare-Nnadi, R., Bernardes-Silva, M., Weller, R. and Perry, V. H. (2004) Traffic of antigen presenting cells to and from the brain Journal of Neuroimmunology, 154, (1-2), pp. 1-230.

More information

Published date: 2004

Identifiers

Local EPrints ID: 37783
URI: http://eprints.soton.ac.uk/id/eprint/37783
ISSN: 0165-5728
PURE UUID: d0d3515e-bad3-4d6b-b706-93e360713d31

Catalogue record

Date deposited: 01 Jun 2006
Last modified: 17 Jul 2017 15:41

Export record


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×