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Increase in interleukin-1beta in late-life depression

Increase in interleukin-1beta in late-life depression
Increase in interleukin-1beta in late-life depression
OBJECTIVE: Depression has been associated with increases in circulating cytokines in younger adults, and there is evidence for prefrontal inflammation in late-life depression. The authors tested the hypothesis that levels of cytokine interleukin-1ß (IL-1ß) would be higher in subjects with late-life major depression. METHOD: Serum levels of IL-1ß were measured in three groups of subjects who were older than 60: 19 subjects with major depression, 20 subjects with subsyndromal depression, and 21 healthy comparison subjects. The Montgomery-Åsberg Depression Rating Scale and the Geriatric Depression Scale were used to assess severity of depression. RESULTS: Compared with healthy subjects, those with major depression had significantly higher levels of IL-1ß (170%); the higher levels of IL-1ß strongly correlated with current depression severity. There were no significant differences between subjects with subsyndromal depression and the other two groups. CONCLUSIONS: These findings support the existence of an inflammatory response, which may be state dependent, in late-life depression.
1535-7228
175-177
Thomas, Alan J.
de120e93-80c4-4bf1-bf7b-ffc89e3cbf88
Davis, Sue
fbc00485-23b4-44a9-bfff-3ee0cfe4ade2
Morris, Christopher
a5dc6cdc-49e0-4fbb-92e0-7f57811c5dc4
Jackson, Elizabeth
3720dbfe-e761-408e-8e87-70e86e48bbc2
Harrison, Richard
848aa9dc-797f-40f8-b63d-bca0d90f7b55
O'Brien, John T.
245c03f3-bf8c-416d-892e-cdc202d960a6
Thomas, Alan J.
de120e93-80c4-4bf1-bf7b-ffc89e3cbf88
Davis, Sue
fbc00485-23b4-44a9-bfff-3ee0cfe4ade2
Morris, Christopher
a5dc6cdc-49e0-4fbb-92e0-7f57811c5dc4
Jackson, Elizabeth
3720dbfe-e761-408e-8e87-70e86e48bbc2
Harrison, Richard
848aa9dc-797f-40f8-b63d-bca0d90f7b55
O'Brien, John T.
245c03f3-bf8c-416d-892e-cdc202d960a6

Thomas, Alan J., Davis, Sue, Morris, Christopher, Jackson, Elizabeth, Harrison, Richard and O'Brien, John T. (2005) Increase in interleukin-1beta in late-life depression. American Journal of Psychiatry, 162 (1), 175-177.

Record type: Article

Abstract

OBJECTIVE: Depression has been associated with increases in circulating cytokines in younger adults, and there is evidence for prefrontal inflammation in late-life depression. The authors tested the hypothesis that levels of cytokine interleukin-1ß (IL-1ß) would be higher in subjects with late-life major depression. METHOD: Serum levels of IL-1ß were measured in three groups of subjects who were older than 60: 19 subjects with major depression, 20 subjects with subsyndromal depression, and 21 healthy comparison subjects. The Montgomery-Åsberg Depression Rating Scale and the Geriatric Depression Scale were used to assess severity of depression. RESULTS: Compared with healthy subjects, those with major depression had significantly higher levels of IL-1ß (170%); the higher levels of IL-1ß strongly correlated with current depression severity. There were no significant differences between subjects with subsyndromal depression and the other two groups. CONCLUSIONS: These findings support the existence of an inflammatory response, which may be state dependent, in late-life depression.

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Published date: 2005

Identifiers

Local EPrints ID: 37812
URI: http://eprints.soton.ac.uk/id/eprint/37812
ISSN: 1535-7228
PURE UUID: 284eb89a-6782-4b53-9237-b3d32f59c6bd

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Date deposited: 01 Jun 2006
Last modified: 11 Dec 2021 15:38

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Contributors

Author: Alan J. Thomas
Author: Sue Davis
Author: Christopher Morris
Author: Elizabeth Jackson
Author: Richard Harrison
Author: John T. O'Brien

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