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Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder

Thomas, Alan J., Davis, Sue, Ferrier, I. Nicol, Kalaria, Rajesh N. and O'Brien, John T. (2004) Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder Biological Psychiatry, 55, (6), pp. 652-655. (doi:10.1016/j.biopsych.2003.10.015).

Record type: Article


Neuroimaging reports of increases in signal hyperintensities in white and deep gray matter and other work indicate that there might be an inflammatory response in affective disorders.

The microvascular immunoreactivity of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 was measured with image analysis in postmortem tissue from the anterior cingulate cortex (ACC) and dorsolateral prefrontal cortex (DLPFC) from 15 unipolar and 15 bipolar subjects and compared with each other and with 15 subjects with schizophrenia and 15 control subjects.

Intercellular adhesion molecule-1 immunoreactivity in gray and white matter of the ACC in bipolar subjects was increased compared with control subjects (gray: p = .001; white: p < .001) and schizophrenic subjects (gray: p = .016; white: p = .025) and modestly increased in white matter compared with unipolar subjects (p = .049). No such differences were found in the DLPFC.

These findings are consistent with the presence of an inflammatory response in the ACC in bipolar disorder.

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Published date: 2004
Keywords: postmortem, bipolar disorder, cell adhesion molecule, anterior cingulate cortex, dorsolateral prefrontal cortex, inflammation
Organisations: Medical Education


Local EPrints ID: 37813
ISSN: 0006-3223
PURE UUID: 2dd3a1da-89a8-4078-ab7e-55b7f455d0af

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Date deposited: 01 Jun 2006
Last modified: 17 Jul 2017 15:41

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Author: Alan J. Thomas
Author: Sue Davis
Author: I. Nicol Ferrier
Author: Rajesh N. Kalaria
Author: John T. O'Brien

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