The University of Southampton
University of Southampton Institutional Repository

Evidence for a possible role for nitric oxide in the modulation of heart activity in Achatina fulica and Helix aspersa

Record type: Article

The effects of nitric oxide (NO) donors, S-nitroso-N-acetylpenicillamine, S-nitroso--glutathione, sodium nitroprusside and sodium nitrite were investigated on the activity of the isolated hearts of Achatina fulica and Helix aspersa. NO donors inhibited heart activity in a concentration-dependent manner. The only exception was sodium nitroprusside, which excited H. aspersa heart. The inhibitory effects of these NO donors were reduced by the NO scavenger, methylene blue, the guanylyl cyclase inhibitor, 1H-(1,2,4) Oxadiazolo(4,3-a)quinoxalin-1-one (ODQ), and potentiated by 8-Br-cGMP and the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX). Acetylcholine also inhibited the heart activity, and this inhibition was reduced by methylene blue and ODQ. Positive NADPH-diaphorase staining was located in the outer pericardial layer of the heart of A. fulica. The present results provide evidence that NO may modulate the activity of gastropod hearts, and this modulation may modify the inhibitory action of acetylcholine on heart activity.

Full text not available from this repository.

Citation

White, A.R., Curtis, S.A. and Walker, R.J. (2004) Evidence for a possible role for nitric oxide in the modulation of heart activity in Achatina fulica and Helix aspersa Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology, 137, (2), pp. 95-108. (doi:10.1016/j.cca.2003.11.009).

More information

Published date: 2004
Keywords: achatina fulica, helix aspersa, nitric oxide, cGMP, guanylyl cyclase, SNAP, SNOG, ODQ, heart

Identifiers

Local EPrints ID: 37823
URI: http://eprints.soton.ac.uk/id/eprint/37823
ISSN: 1532-0456
PURE UUID: d4da45c7-f987-4d0d-8fc1-8c741c7dd542

Catalogue record

Date deposited: 01 Jun 2006
Last modified: 17 Jul 2017 15:41

Export record

Altmetrics


Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×