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Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream

Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream
Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream
In the absence of sufficient cleaning of medical instruments, contamination and infection can result in serious consequences for the health sector and remains a significant unmet challenge. In this paper we describe a novel cleaning system reliant on cavitation action created in a free flowing fluid stream where ultrasonic transmission to a surface, through the stream, is achieved using careful design and control of the device architecture, sound field and the materials employed. Cleaning was achieved with purified water at room temperature, moderate fluid flow rates and without the need for chemical additives or the high power consumption associated with conventional strategies. This study illustrates the potential in harnessing an ultrasonically activated stream to remove biological contamination including brain tissue from surgical stainless steel substrates, S. epidermidis biofilms from glass, and fat/soft tissue matter from bone structures with considerable basic and clinical applications.
cold water, cleaning, brain proteins, biofilm, bone, ultrasonically activated stream: untrasound
1463-9076
20574-20579
Birkin, P.R.
ba466560-f27c-418d-89fc-67ea4f81d0a7
Offin, D.G.
b50fb831-2455-4ec3-a599-71ae4e7f235b
Vian, C.J.B.
c5ca4c67-5a34-475e-b99b-04593f9c6cc9
Howlin, R.P.
832d22df-7fe4-4c6e-9bb8-05afc6af21bc
Dawson, J.L.
ebbeadb5-5ff9-43c7-8309-2012b9f63641
Secker, T.L.
16b0a878-984f-4272-bfaa-667c7c63023a
Hervé, R.
9baddc65-93cf-4a18-9388-088d60572b06
Stoodley, P.
08614665-92a9-4466-806e-20c6daeb483f
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Keevil, C.W.
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
Leighton, T.G.
3e5262ce-1d7d-42eb-b013-fcc5c286bbae
Birkin, P.R.
ba466560-f27c-418d-89fc-67ea4f81d0a7
Offin, D.G.
b50fb831-2455-4ec3-a599-71ae4e7f235b
Vian, C.J.B.
c5ca4c67-5a34-475e-b99b-04593f9c6cc9
Howlin, R.P.
832d22df-7fe4-4c6e-9bb8-05afc6af21bc
Dawson, J.L.
ebbeadb5-5ff9-43c7-8309-2012b9f63641
Secker, T.L.
16b0a878-984f-4272-bfaa-667c7c63023a
Hervé, R.
9baddc65-93cf-4a18-9388-088d60572b06
Stoodley, P.
08614665-92a9-4466-806e-20c6daeb483f
Oreffo, R.O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Keevil, C.W.
cb7de0a7-ce33-4cfa-af52-07f99e5650eb
Leighton, T.G.
3e5262ce-1d7d-42eb-b013-fcc5c286bbae

Birkin, P.R., Offin, D.G., Vian, C.J.B., Howlin, R.P., Dawson, J.L., Secker, T.L., Hervé, R., Stoodley, P., Oreffo, R.O.C., Keevil, C.W. and Leighton, T.G. (2015) Cold water cleaning of brain proteins, biofilm and bone - harnessing an ultrasonically activated stream. Physical Chemistry Chemical Physics, 17 (32), 20574-20579. (PMID:26200694)

Record type: Article

Abstract

In the absence of sufficient cleaning of medical instruments, contamination and infection can result in serious consequences for the health sector and remains a significant unmet challenge. In this paper we describe a novel cleaning system reliant on cavitation action created in a free flowing fluid stream where ultrasonic transmission to a surface, through the stream, is achieved using careful design and control of the device architecture, sound field and the materials employed. Cleaning was achieved with purified water at room temperature, moderate fluid flow rates and without the need for chemical additives or the high power consumption associated with conventional strategies. This study illustrates the potential in harnessing an ultrasonically activated stream to remove biological contamination including brain tissue from surgical stainless steel substrates, S. epidermidis biofilms from glass, and fat/soft tissue matter from bone structures with considerable basic and clinical applications.

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More information

Accepted/In Press date: 27 June 2015
e-pub ahead of print date: 22 July 2015
Published date: 28 August 2015
Keywords: cold water, cleaning, brain proteins, biofilm, bone, ultrasonically activated stream: untrasound
Organisations: Chemistry, Acoustics Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, nCATS Group, Centre for Biological Sciences

Identifiers

Local EPrints ID: 378564
URI: https://eprints.soton.ac.uk/id/eprint/378564
ISSN: 1463-9076
PURE UUID: b7a1fac4-08ba-477a-b045-152cdb00e4d7
ORCID for P.R. Birkin: ORCID iD orcid.org/0000-0002-6656-4074
ORCID for T.L. Secker: ORCID iD orcid.org/0000-0001-7168-8592
ORCID for R.O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726
ORCID for C.W. Keevil: ORCID iD orcid.org/0000-0003-1917-7706
ORCID for T.G. Leighton: ORCID iD orcid.org/0000-0002-1649-8750

Catalogue record

Date deposited: 01 Jul 2015 14:16
Last modified: 14 Jul 2018 00:36

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Contributors

Author: P.R. Birkin ORCID iD
Author: D.G. Offin
Author: C.J.B. Vian
Author: R.P. Howlin
Author: J.L. Dawson
Author: T.L. Secker ORCID iD
Author: R. Hervé
Author: P. Stoodley
Author: R.O.C. Oreffo ORCID iD
Author: C.W. Keevil ORCID iD
Author: T.G. Leighton ORCID iD

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