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Analysis of microglial proliferation in Alzheimer’s disease

Analysis of microglial proliferation in Alzheimer’s disease
Analysis of microglial proliferation in Alzheimer’s disease
The expansion and activation of the microglial population is a hallmark of many neurodegenerative diseases. Despite this fact, little quantitative information is available for specific neurodegenerative disorders, particularly for Alzheimer’s disease (AD). Determining the degree of local proliferation will not only open avenues into understanding the dynamics of microglial proliferation, but also provide an effective target to design strategies with therapeutic potential. Here we describe immunohistochemical methods to analyse microglial proliferation in both transgenic murine models of AD and in human post-mortem samples, to provide a broad picture of the microglial response at the different experimental levels. The application of a common and universal method to analyse the microglial dynamics across different laboratories will help to understand the contribution of these cells to the pathology of AD and other neurodegenerative diseases.
978-1-4939-2627-5
1064-3745
185-193
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Castrillo, Juan I.
98ff8853-3931-4bef-9381-58decdb9d4c2
Oliver, Stephen G.
c3de796f-4c50-4812-a383-208f23b3cd32
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Perry, V.H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Castrillo, Juan I.
98ff8853-3931-4bef-9381-58decdb9d4c2
Oliver, Stephen G.
c3de796f-4c50-4812-a383-208f23b3cd32

Gomez-Nicola, Diego and Perry, V.H. , Castrillo, Juan I. and Oliver, Stephen G. (eds.) (2015) Analysis of microglial proliferation in Alzheimer’s disease. [in special issue: Systems Biology of Alzheimer's Disease] Methods in Molecular biology, 1303, part II, 185-193. (doi:10.1007/978-1-4939-2627-5_10). (PMID:26235067)

Record type: Article

Abstract

The expansion and activation of the microglial population is a hallmark of many neurodegenerative diseases. Despite this fact, little quantitative information is available for specific neurodegenerative disorders, particularly for Alzheimer’s disease (AD). Determining the degree of local proliferation will not only open avenues into understanding the dynamics of microglial proliferation, but also provide an effective target to design strategies with therapeutic potential. Here we describe immunohistochemical methods to analyse microglial proliferation in both transgenic murine models of AD and in human post-mortem samples, to provide a broad picture of the microglial response at the different experimental levels. The application of a common and universal method to analyse the microglial dynamics across different laboratories will help to understand the contribution of these cells to the pathology of AD and other neurodegenerative diseases.

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More information

Published date: 14 August 2015
Organisations: Biomedicine

Identifiers

Local EPrints ID: 378826
URI: https://eprints.soton.ac.uk/id/eprint/378826
ISBN: 978-1-4939-2627-5
ISSN: 1064-3745
PURE UUID: d0ee50a6-7cff-4eae-9033-e2b7ac1e9a00
ORCID for Diego Gomez-Nicola: ORCID iD orcid.org/0000-0002-5316-2682

Catalogue record

Date deposited: 16 Jul 2015 13:03
Last modified: 06 Jun 2018 12:33

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