The University of Southampton
University of Southampton Institutional Repository

Strategies for improving early detection and diagnosis of neovascular age-related macular degeneration

Strategies for improving early detection and diagnosis of neovascular age-related macular degeneration
Strategies for improving early detection and diagnosis of neovascular age-related macular degeneration
Treatment of the neovascular form of age-related macular degeneration (AMD) has been revolutionized by the introduction of such agents as ranibizumab, bevacizumab, and aflibercept. As a result, the incidence of legal blindness occurring secondary to AMD has fallen dramatically in recent years in many countries. While these agents have undoubtedly been successful in reducing visual impairment and blindness, patients with neovascular AMD typically lose some vision over time, and often lose the ability to read, drive, or perform other important activities of daily living. Efforts are therefore under way to develop strategies that allow for earlier detection and treatment of this disease. In this review, we begin by providing an overview of the rationale for, and the benefits of, early detection and treatment of neovascular AMD. To achieve this, we begin by providing an overview of the pathophysiology and natural history of choroidal neovascularization, before reviewing the evidence from both clinical trials and "real-world" outcome studies. We continue by highlighting an area that is often overlooked: the importance of patient education and awareness for early AMD detection. We conclude the review by reviewing an array of both established and emerging technologies for early detection of choroidal neovascularization, ranging from Amsler chart testing, to hyperacuity testing, to advanced imaging techniques, such as optical coherence tomography.
amsler, detection, choroidal neovascularization, hyperacuity, optical coherence tomography
1177-5467
353-366
Keane, Pearse A.
dddbb07e-a27a-43e7-a7bc-246fb004878a
De Salvo, Gabriella
a747876b-c03d-4655-b31c-735e0f2920d2
Sim, Dawn A.
038c56a4-5440-436d-8357-f3a4a79581ef
Goverdhan, Srini
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Agrawal, Rupesh
edfa1b0b-9c3e-4980-9cf7-1c042308ba9c
Tufail, Adnan
4370b3b4-906d-4fe5-92bd-e6207fa1d59b
Keane, Pearse A.
dddbb07e-a27a-43e7-a7bc-246fb004878a
De Salvo, Gabriella
a747876b-c03d-4655-b31c-735e0f2920d2
Sim, Dawn A.
038c56a4-5440-436d-8357-f3a4a79581ef
Goverdhan, Srini
9ae32d5a-5c82-48a4-962d-1ed8acc3991e
Agrawal, Rupesh
edfa1b0b-9c3e-4980-9cf7-1c042308ba9c
Tufail, Adnan
4370b3b4-906d-4fe5-92bd-e6207fa1d59b

Keane, Pearse A., De Salvo, Gabriella, Sim, Dawn A., Goverdhan, Srini, Agrawal, Rupesh and Tufail, Adnan (2015) Strategies for improving early detection and diagnosis of neovascular age-related macular degeneration. Clinical Ophthalmology, 9, 353-366. (doi:10.2147/OPTH.S59012). (PMID:25733802)

Record type: Article

Abstract

Treatment of the neovascular form of age-related macular degeneration (AMD) has been revolutionized by the introduction of such agents as ranibizumab, bevacizumab, and aflibercept. As a result, the incidence of legal blindness occurring secondary to AMD has fallen dramatically in recent years in many countries. While these agents have undoubtedly been successful in reducing visual impairment and blindness, patients with neovascular AMD typically lose some vision over time, and often lose the ability to read, drive, or perform other important activities of daily living. Efforts are therefore under way to develop strategies that allow for earlier detection and treatment of this disease. In this review, we begin by providing an overview of the rationale for, and the benefits of, early detection and treatment of neovascular AMD. To achieve this, we begin by providing an overview of the pathophysiology and natural history of choroidal neovascularization, before reviewing the evidence from both clinical trials and "real-world" outcome studies. We continue by highlighting an area that is often overlooked: the importance of patient education and awareness for early AMD detection. We conclude the review by reviewing an array of both established and emerging technologies for early detection of choroidal neovascularization, ranging from Amsler chart testing, to hyperacuity testing, to advanced imaging techniques, such as optical coherence tomography.

Text
OPTH-59012-strategies-for-improving-early-detection-and-diagnosis-of-ag_021715.pdf - Accepted Manuscript
Available under License Other.
Download (341kB)

More information

Accepted/In Press date: 16 December 2014
e-pub ahead of print date: February 2015
Published date: 17 February 2015
Keywords: amsler, detection, choroidal neovascularization, hyperacuity, optical coherence tomography
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 378922
URI: https://eprints.soton.ac.uk/id/eprint/378922
ISSN: 1177-5467
PURE UUID: 20960cea-351e-4d2d-92cf-ee900ebee80e

Catalogue record

Date deposited: 21 Jul 2015 12:39
Last modified: 08 Jun 2018 16:32

Export record

Altmetrics

Contributors

Author: Pearse A. Keane
Author: Gabriella De Salvo
Author: Dawn A. Sim
Author: Srini Goverdhan
Author: Rupesh Agrawal
Author: Adnan Tufail

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×