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Reliability of oscillometric central hemodynamic responses to an orthostatic challenge

Reliability of oscillometric central hemodynamic responses to an orthostatic challenge
Reliability of oscillometric central hemodynamic responses to an orthostatic challenge
Background

Monitoring central hemodynamic responses to an orthostatic challenge may provide important insight into autonomic nervous system function. Oscillometric pulse wave analysis devices have recently emerged, presenting clinically viable options for investigating central hemodynamic properties. The purpose of the current study was to determine whether oscillometric pulse wave analysis can be used to reliably (between-day) assess central blood pressure and central pressure augmentation (augmentation index) responses to a 5 min orthostatic challenge (modified tilt-table).

Methods

Twenty healthy adults (26.4 y (SD 5.2), 55% F, 24.7 kg/m2 (SD 3.8)) were tested on 3 different mornings in the fasted state, separated by a maximum of 7 days. Central hemodynamic variables were assessed on the left arm using an oscillometric device.

Results

Repeated measures analysis of variance indicated a significant main effect of the modified tilt-table for all central hemodynamic variables (P < 0.001). In response to the tilt, central diastolic pressure increased by 4.5 mmHg (CI: 2.6, 6.4), central systolic blood pressure increased by 2.3 (CI: 4.4, 0.16) mmHg, and augmentation index decreased by an absolute – 5.3%, (CI: ?2.7, ?7.9%). The intra-class correlation coefficient values for central diastolic pressure (0.83–0.86), central systolic blood pressure (0.80–0.87) and AIx (0.79–0.82) were above the 0.75 criterion in both the supine and tilted positions, indicating excellent between-day reliability.

Conclusion

Central hemodynamic responses to an orthostatic challenge can be assessed with acceptable between-day reliability using oscillometric pulse wave analysis.
pulse wave analysis, orthostatic challenge, central blood pressure, arterial wave reflection, augmentation index
0021-9150
761-765
Stoner, Lee
0f9dd581-205f-490d-8879-7ba7cfa51450
Bonner, Chantel
e207309c-266e-45d3-b11d-58919c7af315
Credeur, Daniel
26c4d16b-5809-4e5c-842c-d559464e947c
Lambrick, Danielle
1deafa4b-acf3-4eff-83c9-f8274e47e993
Faulkner, James
1bedc0f0-8fa4-4bf3-8e31-abd084b0c148
Wadsworth, Daniel
69e655d2-f1ae-4dc3-9232-13f5ea771618
Williams, Michelle A.
90364b54-80d0-4070-ace1-349149da998e
Stoner, Lee
0f9dd581-205f-490d-8879-7ba7cfa51450
Bonner, Chantel
e207309c-266e-45d3-b11d-58919c7af315
Credeur, Daniel
26c4d16b-5809-4e5c-842c-d559464e947c
Lambrick, Danielle
1deafa4b-acf3-4eff-83c9-f8274e47e993
Faulkner, James
1bedc0f0-8fa4-4bf3-8e31-abd084b0c148
Wadsworth, Daniel
69e655d2-f1ae-4dc3-9232-13f5ea771618
Williams, Michelle A.
90364b54-80d0-4070-ace1-349149da998e

Stoner, Lee, Bonner, Chantel, Credeur, Daniel, Lambrick, Danielle, Faulkner, James, Wadsworth, Daniel and Williams, Michelle A. (2015) Reliability of oscillometric central hemodynamic responses to an orthostatic challenge. Atherosclerosis, 241 (2), 761-765. (doi:10.1016/j.atherosclerosis.2015.06.041). (PMID:26142686)

Record type: Article

Abstract

Background

Monitoring central hemodynamic responses to an orthostatic challenge may provide important insight into autonomic nervous system function. Oscillometric pulse wave analysis devices have recently emerged, presenting clinically viable options for investigating central hemodynamic properties. The purpose of the current study was to determine whether oscillometric pulse wave analysis can be used to reliably (between-day) assess central blood pressure and central pressure augmentation (augmentation index) responses to a 5 min orthostatic challenge (modified tilt-table).

Methods

Twenty healthy adults (26.4 y (SD 5.2), 55% F, 24.7 kg/m2 (SD 3.8)) were tested on 3 different mornings in the fasted state, separated by a maximum of 7 days. Central hemodynamic variables were assessed on the left arm using an oscillometric device.

Results

Repeated measures analysis of variance indicated a significant main effect of the modified tilt-table for all central hemodynamic variables (P < 0.001). In response to the tilt, central diastolic pressure increased by 4.5 mmHg (CI: 2.6, 6.4), central systolic blood pressure increased by 2.3 (CI: 4.4, 0.16) mmHg, and augmentation index decreased by an absolute – 5.3%, (CI: ?2.7, ?7.9%). The intra-class correlation coefficient values for central diastolic pressure (0.83–0.86), central systolic blood pressure (0.80–0.87) and AIx (0.79–0.82) were above the 0.75 criterion in both the supine and tilted positions, indicating excellent between-day reliability.

Conclusion

Central hemodynamic responses to an orthostatic challenge can be assessed with acceptable between-day reliability using oscillometric pulse wave analysis.

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More information

Accepted/In Press date: 22 June 2015
e-pub ahead of print date: 27 June 2015
Published date: August 2015
Keywords: pulse wave analysis, orthostatic challenge, central blood pressure, arterial wave reflection, augmentation index
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 378946
URI: http://eprints.soton.ac.uk/id/eprint/378946
ISSN: 0021-9150
PURE UUID: d2e7c298-4b8d-438f-92dd-be316920627d
ORCID for Danielle Lambrick: ORCID iD orcid.org/0000-0002-0325-6015

Catalogue record

Date deposited: 15 Jul 2015 09:35
Last modified: 17 Sep 2019 00:38

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