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Screening for cognitive deficit in 8 to 14 year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life

Screening for cognitive deficit in 8 to 14 year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life
Screening for cognitive deficit in 8 to 14 year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life
Background We aimed to identify a brief screening measure for detection of cognitive deficit in children treated for cerebellar tumors that would be useful in clinical practice.

Methods A sample of 72 children aged 8-14 years and within three years post-diagnosis for standard risk medulloblastoma (n=37) or low grade cerebellar astrocytoma (n=35) and 38 in a non-tumor group were assessed using teacher-, parent-, and child-report of the Behavior Rating Inventory of Executive Function (BRIEF), Strengths and Difficulties Questionnaire (SDQ), and Pediatric Quality of Life Inventory (PedsQL). The accuracy of these scores as a screen for a full scale Intelligence Quotient (FSIQ) <80 on the Wechsler Intelligence Scale for Children (WISC®-IV UK) was assessed using their receiver operating characteristic (ROC) curves.

Results The questionnaires with the highest areas under the ROC curves were the child- and parent-report PedsQL and the teacher-report BRIEF and SDQ. At optimal cut-off scores, their sensitivities (95% CIs) to cases of FSIQ<80 were 84 (60-96)%, 65 (41-84)%, 79 (54-93)%, and 84 (60-96)% and their specificities (95% CIs) were 79 (68-86)%, 87 (77-93)%, 77 (66-86)%, and 71 (64-84)% respectively. All cases of FSIQ<80 screened positive on either teacher-report SDQ or self-report PedsQL.

Conclusions The PedsQL child- and parent-report and the teacher-report BRIEF and SDQ have moderately good accuracy to discriminate between children with and without a FSIQ<80. The PedsQL could be used in a clinical setting, and the BRIEF and SDQ in an educational setting, to screen for cases with FSIQ<80 in children treated for brain tumors.
screening, cognitive deficit, children, cerebellar tumors, health-related quality of life
1522-8517
1-31
Bull, K.S.
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Liossi, Christina
fd401ad6-581a-4a31-a60b-f8671ffd3558
Peacock, Janet
62df4239-ae7e-44cf-aa3c-3c2e7f1e511c
Yuen, Ho Ming
b1df4c57-0c2a-44ac-ab40-22b88e8effe8
Kennedy, Colin
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93
Bull, K.S.
751f8b25-29ba-4d4f-96e2-6c339a83a47f
Liossi, Christina
fd401ad6-581a-4a31-a60b-f8671ffd3558
Peacock, Janet
62df4239-ae7e-44cf-aa3c-3c2e7f1e511c
Yuen, Ho Ming
b1df4c57-0c2a-44ac-ab40-22b88e8effe8
Kennedy, Colin
7c3aff62-0a86-4b44-b7d7-4bc01f23ec93

Bull, K.S., Liossi, Christina, Peacock, Janet, Yuen, Ho Ming and Kennedy, Colin (2015) Screening for cognitive deficit in 8 to 14 year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life. Neuro-Oncology, 1-31. (doi:10.1093/neuonc/nov129).

Record type: Article

Abstract

Background We aimed to identify a brief screening measure for detection of cognitive deficit in children treated for cerebellar tumors that would be useful in clinical practice.

Methods A sample of 72 children aged 8-14 years and within three years post-diagnosis for standard risk medulloblastoma (n=37) or low grade cerebellar astrocytoma (n=35) and 38 in a non-tumor group were assessed using teacher-, parent-, and child-report of the Behavior Rating Inventory of Executive Function (BRIEF), Strengths and Difficulties Questionnaire (SDQ), and Pediatric Quality of Life Inventory (PedsQL). The accuracy of these scores as a screen for a full scale Intelligence Quotient (FSIQ) <80 on the Wechsler Intelligence Scale for Children (WISC®-IV UK) was assessed using their receiver operating characteristic (ROC) curves.

Results The questionnaires with the highest areas under the ROC curves were the child- and parent-report PedsQL and the teacher-report BRIEF and SDQ. At optimal cut-off scores, their sensitivities (95% CIs) to cases of FSIQ<80 were 84 (60-96)%, 65 (41-84)%, 79 (54-93)%, and 84 (60-96)% and their specificities (95% CIs) were 79 (68-86)%, 87 (77-93)%, 77 (66-86)%, and 71 (64-84)% respectively. All cases of FSIQ<80 screened positive on either teacher-report SDQ or self-report PedsQL.

Conclusions The PedsQL child- and parent-report and the teacher-report BRIEF and SDQ have moderately good accuracy to discriminate between children with and without a FSIQ<80. The PedsQL could be used in a clinical setting, and the BRIEF and SDQ in an educational setting, to screen for cases with FSIQ<80 in children treated for brain tumors.

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Accepted ROC paper Bull et al Neuro-oncology 120615 cut down.pdf - Accepted Manuscript
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More information

Accepted/In Press date: 12 June 2015
e-pub ahead of print date: 22 July 2015
Published date: 1 December 2015
Keywords: screening, cognitive deficit, children, cerebellar tumors, health-related quality of life
Organisations: Faculty of Medicine, Psychology

Identifiers

Local EPrints ID: 379176
URI: https://eprints.soton.ac.uk/id/eprint/379176
ISSN: 1522-8517
PURE UUID: dfc5b919-4679-4bbe-967a-c91df9574a00
ORCID for K.S. Bull: ORCID iD orcid.org/0000-0002-5541-4556
ORCID for Christina Liossi: ORCID iD orcid.org/0000-0003-0627-6377

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Date deposited: 15 Jul 2015 14:04
Last modified: 20 Jul 2019 01:09

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Contributors

Author: K.S. Bull ORCID iD
Author: Janet Peacock
Author: Ho Ming Yuen
Author: Colin Kennedy

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