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Dementia of the eye: the role of amyloid beta in retinal degeneration

Dementia of the eye: the role of amyloid beta in retinal degeneration
Dementia of the eye: the role of amyloid beta in retinal degeneration
Age-related macular degeneration (AMD) is one of the most common causes of irreversible blindness affecting nearly 50 million individuals globally. The disease is characterised by progressive loss of central vision, which has significant implications for quality of life concerns in an increasingly ageing population. AMD pathology manifests in the macula, a specialised region of the retina, which is responsible for central vision and perception of fine details. The underlying pathology of this complex degenerative disease is incompletely understood but includes both genetic as well as epigenetic risk factors. The recent discovery that amyloid beta (A?), a highly toxic and aggregate-prone family of peptides, is elevated in the ageing retina and is associated with AMD has opened up new perspectives on the aetiology of this debilitating blinding disease. Multiple studies now link A? with key stages of AMD progression, which is both exciting and potentially insightful, as this identifies a well-established toxic agent that aggressively targets cells in degenerative brains. Here, we review the most recent findings supporting the hypothesis that A? may be a key factor in AMD pathology. We describe how multiple A? reservoirs, now reported in the ageing eye, may target the cellular physiology of the retina as well as associated layers, and propose a mechanistic pathway of A?-mediated degenerative change leading to AMD.
0950-222X
1-14
Ratnayaka, J.A.
002499b8-1a9f-45b6-9539-5ac145799dfd
Serpell, L.C.
2a7e3bc9-35a1-4995-944c-b58995de7803
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Ratnayaka, J.A.
002499b8-1a9f-45b6-9539-5ac145799dfd
Serpell, L.C.
2a7e3bc9-35a1-4995-944c-b58995de7803
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514

Ratnayaka, J.A., Serpell, L.C. and Lotery, A.J. (2015) Dementia of the eye: the role of amyloid beta in retinal degeneration. Eye, 1-14. (doi:10.1038/eye.2015.100). (PMID:26088679)

Record type: Article

Abstract

Age-related macular degeneration (AMD) is one of the most common causes of irreversible blindness affecting nearly 50 million individuals globally. The disease is characterised by progressive loss of central vision, which has significant implications for quality of life concerns in an increasingly ageing population. AMD pathology manifests in the macula, a specialised region of the retina, which is responsible for central vision and perception of fine details. The underlying pathology of this complex degenerative disease is incompletely understood but includes both genetic as well as epigenetic risk factors. The recent discovery that amyloid beta (A?), a highly toxic and aggregate-prone family of peptides, is elevated in the ageing retina and is associated with AMD has opened up new perspectives on the aetiology of this debilitating blinding disease. Multiple studies now link A? with key stages of AMD progression, which is both exciting and potentially insightful, as this identifies a well-established toxic agent that aggressively targets cells in degenerative brains. Here, we review the most recent findings supporting the hypothesis that A? may be a key factor in AMD pathology. We describe how multiple A? reservoirs, now reported in the ageing eye, may target the cellular physiology of the retina as well as associated layers, and propose a mechanistic pathway of A?-mediated degenerative change leading to AMD.

Other
Abeta and AMD Review for Eye journal_Final Version.docx - Accepted Manuscript
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More information

Accepted/In Press date: 23 April 2015
Published date: 19 June 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 379186
URI: https://eprints.soton.ac.uk/id/eprint/379186
ISSN: 0950-222X
PURE UUID: 18251638-bf5a-4f7a-99ed-c293e6d62f46
ORCID for J.A. Ratnayaka: ORCID iD orcid.org/0000-0002-1027-6938
ORCID for A.J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305

Catalogue record

Date deposited: 15 Jul 2015 15:48
Last modified: 31 Jan 2019 01:36

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