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The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer

The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer
The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer
BACKGROUND: The ability to identify men at genetically high-risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa-specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic-risk profiling, within a research study.

METHODS: A prospective exploratory approach was adopted, incorporating a sequential mixed-method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic-risk profiling. In-depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach.

RESULTS: Ninety-five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: 'feeling at risk' and 'living with risk'. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results.

CONCLUSIONS: Personalised genetic-risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research
Bancroft, Elizabeth K.
192e818b-3694-4987-b466-b890669e28ca
Castro, Elena
c7e21bea-2fec-4682-b744-051720d4a6ce
Bancroft, Gordon A.
fd1dd46a-5304-4420-81b2-4aee4c20a4b2
Ardern-Jones, Audrey
312b76d6-ceac-49a7-b3ef-1b04688686f3
Moynihan, Clare
5830406c-b68c-4ec6-ac83-833c2af9b095
Page, Elizabeth
7e14b568-da27-48c8-b20f-c4388bc75365
Taylor, Natalie
79383ca7-b6b0-4e56-915c-5fa8eccaa6b3
Eeles, Rosalind A.
b11a81ed-c0fc-4edc-a3b9-bbc300f19576
Rowley, Emma
cdcd5a9c-a03e-41bf-8cef-e239aa7e4ab8
Cox, Karen
10ca3ab1-b308-44f3-9dcd-75a522220bf0
Bancroft, Elizabeth K.
192e818b-3694-4987-b466-b890669e28ca
Castro, Elena
c7e21bea-2fec-4682-b744-051720d4a6ce
Bancroft, Gordon A.
fd1dd46a-5304-4420-81b2-4aee4c20a4b2
Ardern-Jones, Audrey
312b76d6-ceac-49a7-b3ef-1b04688686f3
Moynihan, Clare
5830406c-b68c-4ec6-ac83-833c2af9b095
Page, Elizabeth
7e14b568-da27-48c8-b20f-c4388bc75365
Taylor, Natalie
79383ca7-b6b0-4e56-915c-5fa8eccaa6b3
Eeles, Rosalind A.
b11a81ed-c0fc-4edc-a3b9-bbc300f19576
Rowley, Emma
cdcd5a9c-a03e-41bf-8cef-e239aa7e4ab8
Cox, Karen
10ca3ab1-b308-44f3-9dcd-75a522220bf0

Bancroft, Elizabeth K., Castro, Elena, Bancroft, Gordon A., Ardern-Jones, Audrey, Moynihan, Clare, Page, Elizabeth, Taylor, Natalie, Eeles, Rosalind A., Rowley, Emma and Cox, Karen (2015) The psychological impact of undergoing genetic-risk profiling in men with a family history of prostate cancer. Psycho-Oncology. (doi:10.1002/pon.3814). (PMID:25872100)

Record type: Article

Abstract

BACKGROUND: The ability to identify men at genetically high-risk of prostate cancer (PrCa) would enable screening to be targeted at those most in need. This study explored the psychological impact (in terms of general and PrCa-specific worry and risk perceptions) on men with a family history of PrCa, undergoing prostate screening and genetic-risk profiling, within a research study.

METHODS: A prospective exploratory approach was adopted, incorporating a sequential mixed-method design. Questionnaires were completed at two time points to measure the impact of undergoing screening and genetic-risk profiling. In-depth interviews were completed in a subgroup after all study procedures were completed and analysed using a framework approach.

RESULTS: Ninety-five men completed both questionnaires, and 26 were interviewed. No measurable psychological distress was detectable in the group as a whole. The interview findings fell into two categories: 'feeling at risk' and 'living with risk'. The feeling of being at risk of PrCa is a part of men's lives, shaped by assumptions and information gathered over many years. Men used this information to communicate about PrCa risk to their peers. Men overestimate their risk of PrCa and have an innate assumption that they will develop PrCa. The interviews revealed that men experienced acute anxiety when waiting for screening results.

CONCLUSIONS: Personalised genetic-risk assessments do not prevent men from overestimating their risk of PrCa. Screening anxiety is common, and timeframes for receiving results should be kept to a minimum. Methods of risk communication in men at risk of PrCa should be the subject of future research

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More information

Accepted/In Press date: 13 February 2015
e-pub ahead of print date: 14 April 2015
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 379403
URI: https://eprints.soton.ac.uk/id/eprint/379403
PURE UUID: 4de528fb-6fd3-4934-b820-cadd67f8075a

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Date deposited: 28 Jul 2015 10:39
Last modified: 15 Jul 2019 21:11

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Contributors

Author: Elizabeth K. Bancroft
Author: Elena Castro
Author: Gordon A. Bancroft
Author: Audrey Ardern-Jones
Author: Clare Moynihan
Author: Elizabeth Page
Author: Natalie Taylor
Author: Rosalind A. Eeles
Author: Emma Rowley
Author: Karen Cox

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