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Meta-analysis of clinical trials with rare events

Meta-analysis of clinical trials with rare events
Meta-analysis of clinical trials with rare events
Meta-analysis of rare event studies has recently become a subject of controversy and debate. We will argue and demonstrate in this paper that the occurrence of zero events in clinical trials or cohort studies, even if zeros occur in both arms (the case of a double-zero trial), is less problematic, at least from a statistical perspective, if the available statistical tools are applied in the appropriate way. In particular, it is neither necessary nor advisable to exclude studies with zero events from the meta-analysis. In terms of statistical tools, we will focus here on Mantel–Haenszel techniques, mixed Poisson regression and related regression models
mantel-haenszel estimation, meta-analysis, poisson regression with random effects, rare event analysis, zero and double-zero studies
0323-3847
633-648
Böhning, Dankmar
1df635d4-e3dc-44d0-b61d-5fd11f6434e1
Mylona, Kalliopi
b44af287-2d9f-4df8-931c-32d8ab117864
Kimber, Alan
40ba3a19-bbe3-47b6-9a8d-68ebf4cea774
Böhning, Dankmar
1df635d4-e3dc-44d0-b61d-5fd11f6434e1
Mylona, Kalliopi
b44af287-2d9f-4df8-931c-32d8ab117864
Kimber, Alan
40ba3a19-bbe3-47b6-9a8d-68ebf4cea774

Böhning, Dankmar, Mylona, Kalliopi and Kimber, Alan (2015) Meta-analysis of clinical trials with rare events. Biometrical Journal, 57 (4), 633-648. (doi:10.1002/bimj.201400184).

Record type: Article

Abstract

Meta-analysis of rare event studies has recently become a subject of controversy and debate. We will argue and demonstrate in this paper that the occurrence of zero events in clinical trials or cohort studies, even if zeros occur in both arms (the case of a double-zero trial), is less problematic, at least from a statistical perspective, if the available statistical tools are applied in the appropriate way. In particular, it is neither necessary nor advisable to exclude studies with zero events from the meta-analysis. In terms of statistical tools, we will focus here on Mantel–Haenszel techniques, mixed Poisson regression and related regression models

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More information

Accepted/In Press date: 16 December 2014
e-pub ahead of print date: 27 April 2015
Published date: 1 July 2015
Keywords: mantel-haenszel estimation, meta-analysis, poisson regression with random effects, rare event analysis, zero and double-zero studies
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 379552
URI: http://eprints.soton.ac.uk/id/eprint/379552
ISSN: 0323-3847
PURE UUID: 7b867957-df08-42a1-a4ee-3c8322783927
ORCID for Dankmar Böhning: ORCID iD orcid.org/0000-0003-0638-7106

Catalogue record

Date deposited: 23 Jul 2015 11:03
Last modified: 01 Oct 2019 00:40

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