Pressure induced deep tissue injury explained
Pressure induced deep tissue injury explained
The paper describes the current views on the cause of a sub-class of pressure ulcers known as pressure induced deep tissue injury (DTI). A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals. This has led to a clear understanding on two damage mechanisms associated with the development of DTI. Direct deformation results from high, but physiologically relevant, strains and is a process that leads to the first signs of cell damage within minutes. Ischaemic damage is caused by occlusion of blood vessels, but takes several hours to develop. The paper ends with some clinical consequences.
pressure ulcer, deep tissue injury, pressure sore, aetiology
297-305
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bader, Daniel L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Loerakker, Sandra
77fe9fc8-bedb-4bd7-a7c1-864755dc0ec6
Baaijens, Frank
a52544ca-7ff4-4d14-a6ad-dc130612c917
February 2015
Oomens, Cees W.J.
e8a85b85-3719-4909-9f82-4f03d8a43263
Bader, Daniel L.
9884d4f6-2607-4d48-bf0c-62bdcc0d1dbf
Loerakker, Sandra
77fe9fc8-bedb-4bd7-a7c1-864755dc0ec6
Baaijens, Frank
a52544ca-7ff4-4d14-a6ad-dc130612c917
Oomens, Cees W.J., Bader, Daniel L., Loerakker, Sandra and Baaijens, Frank
(2015)
Pressure induced deep tissue injury explained.
Annals of Biomedical Engineering, 43 (2), .
(doi:10.1007/s10439-014-1202-6).
(PMID:25480479)
Abstract
The paper describes the current views on the cause of a sub-class of pressure ulcers known as pressure induced deep tissue injury (DTI). A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals. This has led to a clear understanding on two damage mechanisms associated with the development of DTI. Direct deformation results from high, but physiologically relevant, strains and is a process that leads to the first signs of cell damage within minutes. Ischaemic damage is caused by occlusion of blood vessels, but takes several hours to develop. The paper ends with some clinical consequences.
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Accepted/In Press date: 19 November 2014
e-pub ahead of print date: 6 December 2014
Published date: February 2015
Keywords:
pressure ulcer, deep tissue injury, pressure sore, aetiology
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 379933
URI: http://eprints.soton.ac.uk/id/eprint/379933
ISSN: 0090-6964
PURE UUID: 6390844c-fa78-4b8f-881b-3f90a26b26d2
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Date deposited: 01 Sep 2015 09:19
Last modified: 14 Mar 2024 20:51
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Contributors
Author:
Cees W.J. Oomens
Author:
Sandra Loerakker
Author:
Frank Baaijens
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