Cluster randomized trial in the general practice research database: 2. Secondary prevention after first stroke (eCRT study): study protocol for a randomized controlled trial
Cluster randomized trial in the general practice research database: 2. Secondary prevention after first stroke (eCRT study): study protocol for a randomized controlled trial
Background: the purpose of this research is to develop and evaluate methods for conducting pragmatic cluster randomized trials in a primary care electronic database. The proposal describes one application, in a less frequent chronic condition of public health importance, secondary prevention of stroke. A related protocol in antibiotic prescribing was reported previously.
Methods/design: the study aims to implement a cluster randomized trial (CRT) using the electronic patient records of the General Practice Research Database (GPRD) as a sampling frame and data source. The specific objective of the trial is to evaluate the effectiveness of a computer-delivered intervention at enhancing the delivery of stroke secondary prevention in primary care. GPRD family practices will be allocated to the intervention or usual care. The intervention promotes the use of electronic prompts to support adherence with the recommendations of the UK Intercollegiate Stroke Working Party and NICE guidelines for the secondary prevention of stroke in primary care. Primary outcome measure will be the difference in systolic blood pressure between intervention and control trial arms at 12-month follow-up. Secondary outcomes will be differences in serum cholesterol, prescribing of antihypertensive drugs, statins, and antiplatelet therapy. The intervention will continue for 12 months. Information on the utilization of the decision-support tools will also be analyzed.
Discussion: the CRT will investigate the effectiveness of using a computer-delivered intervention to reduce the risk of stroke recurrence following a first stroke event. The study will provide methodological guidance on the implementation of CRTs in electronic databases in primary care.
181
Dregan, Alex
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van Staa, Tjeerd
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Mcdermott, Lisa
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McCann, Gerard
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Ashworth, Mark
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Charlton, Judith
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Wolfe, Charles
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Rudd, Anthony
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Yardley, Lucy
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Gulliford, Martin
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3 October 2012
Dregan, Alex
3e9f701f-54d9-4519-a7b7-e18e05b427c7
van Staa, Tjeerd
062ecdf4-b73c-47b3-ba9e-48aa0a47e519
Mcdermott, Lisa
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McCann, Gerard
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Ashworth, Mark
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Charlton, Judith
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Wolfe, Charles
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Rudd, Anthony
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Yardley, Lucy
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Gulliford, Martin
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Dregan, Alex, van Staa, Tjeerd, Mcdermott, Lisa, McCann, Gerard, Ashworth, Mark, Charlton, Judith, Wolfe, Charles, Rudd, Anthony, Yardley, Lucy and Gulliford, Martin
(2012)
Cluster randomized trial in the general practice research database: 2. Secondary prevention after first stroke (eCRT study): study protocol for a randomized controlled trial.
Trials, 13 (1), .
(doi:10.1186/1745-6215-13-181).
Abstract
Background: the purpose of this research is to develop and evaluate methods for conducting pragmatic cluster randomized trials in a primary care electronic database. The proposal describes one application, in a less frequent chronic condition of public health importance, secondary prevention of stroke. A related protocol in antibiotic prescribing was reported previously.
Methods/design: the study aims to implement a cluster randomized trial (CRT) using the electronic patient records of the General Practice Research Database (GPRD) as a sampling frame and data source. The specific objective of the trial is to evaluate the effectiveness of a computer-delivered intervention at enhancing the delivery of stroke secondary prevention in primary care. GPRD family practices will be allocated to the intervention or usual care. The intervention promotes the use of electronic prompts to support adherence with the recommendations of the UK Intercollegiate Stroke Working Party and NICE guidelines for the secondary prevention of stroke in primary care. Primary outcome measure will be the difference in systolic blood pressure between intervention and control trial arms at 12-month follow-up. Secondary outcomes will be differences in serum cholesterol, prescribing of antihypertensive drugs, statins, and antiplatelet therapy. The intervention will continue for 12 months. Information on the utilization of the decision-support tools will also be analyzed.
Discussion: the CRT will investigate the effectiveness of using a computer-delivered intervention to reduce the risk of stroke recurrence following a first stroke event. The study will provide methodological guidance on the implementation of CRTs in electronic databases in primary care.
Text
1745-6215-13-181.pdf
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More information
Accepted/In Press date: 26 September 2012
Published date: 3 October 2012
Identifiers
Local EPrints ID: 379995
URI: http://eprints.soton.ac.uk/id/eprint/379995
ISSN: 1745-6215
PURE UUID: b56ad454-5135-4192-8eca-129144e9133d
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Date deposited: 28 Aug 2015 10:58
Last modified: 15 Mar 2024 03:00
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Contributors
Author:
Alex Dregan
Author:
Tjeerd van Staa
Author:
Lisa Mcdermott
Author:
Gerard McCann
Author:
Mark Ashworth
Author:
Judith Charlton
Author:
Charles Wolfe
Author:
Anthony Rudd
Author:
Martin Gulliford
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