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A top-down view of the tumor microenvironment: structure, cells and signaling

A top-down view of the tumor microenvironment: structure, cells and signaling
A top-down view of the tumor microenvironment: structure, cells and signaling
It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create "activated" stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).
1-9
Bhome, Rahul
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Bullock, Marc D.
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Al Saihati, Hajir A.
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Goh, Rebecca
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Primrose, John N.
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Sayan, A. Emre
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Mirnezami, Alex H.
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Bhome, Rahul
d7b1e0d3-5925-460a-871d-5f52f69c649b
Bullock, Marc D.
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Al Saihati, Hajir A.
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Goh, Rebecca
68e91653-f551-4e3e-b831-00f4b1718667
Primrose, John N.
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Sayan, A. Emre
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Mirnezami, Alex H.
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Bhome, Rahul, Bullock, Marc D., Al Saihati, Hajir A., Goh, Rebecca, Primrose, John N., Sayan, A. Emre and Mirnezami, Alex H. (2015) A top-down view of the tumor microenvironment: structure, cells and signaling. Frontiers in Cell and Developmental Biology, 3, 1-9. (doi:10.3389/fcell.2015.00033). (PMID:26075202)

Record type: Article

Abstract

It is well established that the tumor microenvironment (TME) contributes to cancer progression. Stromal cells can be divided into mesenchymal, vascular, and immune. Signaling molecules secreted by the tumor corrupts these cells to create "activated" stroma. Equally, the extracellular matrix (ECM) contributes to tumor development and invasion by forming a biologically active scaffold. In this review we describe the key structural, cellular and signaling components of the TME with a perspective on stromal soluble factors and microRNAs (miRNAs).

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Accepted/In Press date: 8 April 2015
Published date: 29 May 2015
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 380008
URI: http://eprints.soton.ac.uk/id/eprint/380008
PURE UUID: 2f20e0ea-009c-4217-9e00-a6238f709419
ORCID for John N. Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 01 Sep 2015 11:11
Last modified: 17 Dec 2019 01:59

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Contributors

Author: Rahul Bhome
Author: Marc D. Bullock
Author: Hajir A. Al Saihati
Author: Rebecca Goh
Author: A. Emre Sayan

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