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Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study

Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study
Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study
Background: Although melatonin is increasingly used for sleep disturbances in children with neurodevelopmental disorders, evidence on effective dose and impact on specific types of sleep disturbance is limited. Method: We assessed 45 children (35 males, mean age: 6.3 ± 1.7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response. Results: Thirty-eight percent of children responded to low (2.5–3 mg), 31% to medium (5–6 mg) and 9% to high doses (9–10 mg) of melatonin, with a significant increase in total hours of sleep/night, decreased sleep onset delay and decreased number of awakenings/night (all: p = 0.001), as measured with sleep diaries. No serious adverse events were reported. Conclusions: Melatonin is generally effective and safe in children with neurodevelopmental conditions. Increasing above 6 mg/night adds further benefit only in a small percentage of children.
attention-deficit/hyperactivity disorder, autism spectrum disorder, children, intellectual disability, melatonin, sleep
1473-7175
711-717
Ayyash, Hani F
6222ddf7-fd8b-43a8-8d76-6d54262e8ef3
Preece, Phillip
ea7644f5-bf70-4385-a2f4-db8513276815
Morton, Richard
27c7164c-6d06-4d73-8f3a-f08d52d1cffd
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Ayyash, Hani F
6222ddf7-fd8b-43a8-8d76-6d54262e8ef3
Preece, Phillip
ea7644f5-bf70-4385-a2f4-db8513276815
Morton, Richard
27c7164c-6d06-4d73-8f3a-f08d52d1cffd
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb

Ayyash, Hani F, Preece, Phillip, Morton, Richard and Cortese, Samuele (2015) Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study. Expert Review of Neurotherapeutics, 15 (6), 711-717. (doi:10.1586/14737175.2015.1041511).

Record type: Article

Abstract

Background: Although melatonin is increasingly used for sleep disturbances in children with neurodevelopmental disorders, evidence on effective dose and impact on specific types of sleep disturbance is limited. Method: We assessed 45 children (35 males, mean age: 6.3 ± 1.7 years) with neurodevelopmental disorders (n = 29: intellectual disability; n = 9: autism spectrum disorder; n = 7: attention-deficit/hyperactivity disorder) and sleep disturbances, treated with melatonin (mean duration: 326 days) with doses increased according to response. Results: Thirty-eight percent of children responded to low (2.5–3 mg), 31% to medium (5–6 mg) and 9% to high doses (9–10 mg) of melatonin, with a significant increase in total hours of sleep/night, decreased sleep onset delay and decreased number of awakenings/night (all: p = 0.001), as measured with sleep diaries. No serious adverse events were reported. Conclusions: Melatonin is generally effective and safe in children with neurodevelopmental conditions. Increasing above 6 mg/night adds further benefit only in a small percentage of children.

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More information

e-pub ahead of print date: 3 June 2015
Keywords: attention-deficit/hyperactivity disorder, autism spectrum disorder, children, intellectual disability, melatonin, sleep
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 380062
URI: https://eprints.soton.ac.uk/id/eprint/380062
ISSN: 1473-7175
PURE UUID: edbbb64c-0b02-48c7-bb03-bd624f7b6f33
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 19 Aug 2015 11:24
Last modified: 06 Jun 2018 12:21

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