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Prevalence of obesity in attention-deficit/hyperactivity disorder: study protocol for a systematic review and meta-analysis

Prevalence of obesity in attention-deficit/hyperactivity disorder: study protocol for a systematic review and meta-analysis
Prevalence of obesity in attention-deficit/hyperactivity disorder: study protocol for a systematic review and meta-analysis
Introduction An increasing number of clinical and epidemiological studies suggest a possible association between attention-deficit/hyperactivity disorder (ADHD) and obesity/overweight. However, overall evidence is mixed. Given the public health relevance of ADHD and obesity/overweight, understanding whether and to what extent they are associated is paramount to plan intervention and prevention strategies. We describe the protocol of a systematic review and meta-analysis aimed at assessing the prevalence of obesity/overweight in individuals with ADHD versus those without ADHD.


Methods and analysis We will include studies of any design (except case reports or case series) comparing the prevalence of obesity and/or overweight in children or adults with and without ADHD (or hyperkinetic disorder). We will search an extensive number of databases including PubMed, Ovid databases, Web of Knowledge and Thomson-Reuters databases, ERIC and CINAHL. No restrictions of language will be applied. We will also contact experts in the field for possible unpublished or in press data. Primary and additional outcomes will be the prevalence of obesity and overweight, respectively. We will combine ORs using random-effects models in STATA V.12.0. The quality of the study will be assessed primarily using the Newcastle-Ottawa Scale. Subgroup meta-analyses will be conducted according to participants’ age (children vs adults) and study setting (clinical vs general population). We will explore the feasibility of conducting meta-regression analyses to assess the moderating effect of age, gender, socioeconomic status, study setting, geographic location of the study (low-income, middle-income countries vs high-income countries), definition of obesity, method to assess ADHD, psychiatric comorbidities and medication status.


Ethics and dissemination No ethical issues are foreseen. The results will be published in a peer-reviewed journal and presented at national and international conferences of psychiatry, psychology, obesity and paediatrics.

Registration PROSPERO-National Institute of Health Research (NIHR) Prospective Register of Systematic Reviews (CRD42013006410).
e004541
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
Moreira Maia, C. R.
7dc72a49-e660-468a-a045-0003a00332ab
Rohde, L. A.
a462c9af-c86b-40f3-ae46-e22c388adb32
Morcillo-Penalver, C.
512b8f1b-1d74-4d45-9899-0d4a27cd6f72
Faraone, S. V.
60d855ed-a8a8-4eca-9e62-965eb021b1e2
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
Moreira Maia, C. R.
7dc72a49-e660-468a-a045-0003a00332ab
Rohde, L. A.
a462c9af-c86b-40f3-ae46-e22c388adb32
Morcillo-Penalver, C.
512b8f1b-1d74-4d45-9899-0d4a27cd6f72
Faraone, S. V.
60d855ed-a8a8-4eca-9e62-965eb021b1e2

Cortese, S., Moreira Maia, C. R., Rohde, L. A., Morcillo-Penalver, C. and Faraone, S. V. (2014) Prevalence of obesity in attention-deficit/hyperactivity disorder: study protocol for a systematic review and meta-analysis. BMJ Open, 4 (3), e004541. (doi:10.1136/bmjopen-2013-004541).

Record type: Article

Abstract

Introduction An increasing number of clinical and epidemiological studies suggest a possible association between attention-deficit/hyperactivity disorder (ADHD) and obesity/overweight. However, overall evidence is mixed. Given the public health relevance of ADHD and obesity/overweight, understanding whether and to what extent they are associated is paramount to plan intervention and prevention strategies. We describe the protocol of a systematic review and meta-analysis aimed at assessing the prevalence of obesity/overweight in individuals with ADHD versus those without ADHD.


Methods and analysis We will include studies of any design (except case reports or case series) comparing the prevalence of obesity and/or overweight in children or adults with and without ADHD (or hyperkinetic disorder). We will search an extensive number of databases including PubMed, Ovid databases, Web of Knowledge and Thomson-Reuters databases, ERIC and CINAHL. No restrictions of language will be applied. We will also contact experts in the field for possible unpublished or in press data. Primary and additional outcomes will be the prevalence of obesity and overweight, respectively. We will combine ORs using random-effects models in STATA V.12.0. The quality of the study will be assessed primarily using the Newcastle-Ottawa Scale. Subgroup meta-analyses will be conducted according to participants’ age (children vs adults) and study setting (clinical vs general population). We will explore the feasibility of conducting meta-regression analyses to assess the moderating effect of age, gender, socioeconomic status, study setting, geographic location of the study (low-income, middle-income countries vs high-income countries), definition of obesity, method to assess ADHD, psychiatric comorbidities and medication status.


Ethics and dissemination No ethical issues are foreseen. The results will be published in a peer-reviewed journal and presented at national and international conferences of psychiatry, psychology, obesity and paediatrics.

Registration PROSPERO-National Institute of Health Research (NIHR) Prospective Register of Systematic Reviews (CRD42013006410).

Full text not available from this repository.

More information

Accepted/In Press date: 17 February 2014
Published date: 18 March 2014
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 380157
URI: https://eprints.soton.ac.uk/id/eprint/380157
PURE UUID: d2ec2c91-595a-4607-95d8-9cba187ad747
ORCID for S. Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 19 Aug 2015 16:53
Last modified: 10 Sep 2019 00:33

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Contributors

Author: S. Cortese ORCID iD
Author: C. R. Moreira Maia
Author: L. A. Rohde
Author: C. Morcillo-Penalver
Author: S. V. Faraone

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