Does psychostimulant treatment in children with ADHD increase later risk of substance use disorder?
Does psychostimulant treatment in children with ADHD increase later risk of substance use disorder?
Psychostimulants are the first choice medication in children with attention-deficit/hyperactivity disorder (ADHD). Despite the proven high efficacy of psychostimulants, at least in the short term, for ADHD core symptoms, concerns continue to be raised on their adverse effects, including putative increased risk of substance use disorders (SUDs). A recent multicentre, case–control, longitudinal, prospective, European study by Groenman and colleagues found that treatment with psychostimulants in children with ADHD lowered the risk of SUDs in adolescence. However, this finding is at odds with other recent evidence concluding that ADHD children with and without medication treatment history did not significantly differ on any subsequent SUDs rates. In the present paper, we discuss the study by Groenman and colleagues in view of its methodological strengths and limitations, and we suggest possible implications for day-to-day clinical practice.
adolescents, attention-deficit/hyperactivity disorder, children, psychostimulants, substance use disorder
133-135
Purgato, M.
c9d151c2-b4f1-452e-b13c-5adee3114ac8
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
June 2014
Purgato, M.
c9d151c2-b4f1-452e-b13c-5adee3114ac8
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
Purgato, M. and Cortese, S.
(2014)
Does psychostimulant treatment in children with ADHD increase later risk of substance use disorder?
Epidemiology and Psychiatric Sciences, 23 (2), .
(doi:10.1017/s2045796014000146).
Abstract
Psychostimulants are the first choice medication in children with attention-deficit/hyperactivity disorder (ADHD). Despite the proven high efficacy of psychostimulants, at least in the short term, for ADHD core symptoms, concerns continue to be raised on their adverse effects, including putative increased risk of substance use disorders (SUDs). A recent multicentre, case–control, longitudinal, prospective, European study by Groenman and colleagues found that treatment with psychostimulants in children with ADHD lowered the risk of SUDs in adolescence. However, this finding is at odds with other recent evidence concluding that ADHD children with and without medication treatment history did not significantly differ on any subsequent SUDs rates. In the present paper, we discuss the study by Groenman and colleagues in view of its methodological strengths and limitations, and we suggest possible implications for day-to-day clinical practice.
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Accepted/In Press date: 7 February 2014
e-pub ahead of print date: 18 March 2014
Published date: June 2014
Keywords:
adolescents, attention-deficit/hyperactivity disorder, children, psychostimulants, substance use disorder
Organisations:
Clinical Neuroscience
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Local EPrints ID: 380161
URI: http://eprints.soton.ac.uk/id/eprint/380161
ISSN: 2045-7960
PURE UUID: 2a4e214d-a43d-4a75-b02f-25de6f0e90f3
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Date deposited: 20 Aug 2015 14:40
Last modified: 15 Mar 2024 03:52
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Author:
M. Purgato
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