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Sleep alterations in children with refractory epileptic encephalopathies: a polysomnographic study

Sleep alterations in children with refractory epileptic encephalopathies: a polysomnographic study
Sleep alterations in children with refractory epileptic encephalopathies: a polysomnographic study
Data on the relationship between sleep disturbances and refractory epileptic encephalopathies (EEs) are scarce. Our aim was to assess, by means of nocturnal polysomnography, if children with EEs present with objective alterations in sleep organization. Twenty-three children with EEs (12 males; mean age: 8.7 ± 1.4 years) and 40 healthy controls (22 males; mean age: 8.8 ± 1.1 years) underwent an overnight full polysomnography (PSG). Relative to controls, children with EEs showed a significant reduction in all PSG parameters related to sleep duration time in bed (TIB-min p < 0.001), total sleep time (TST-min p < 0.001), and sleep percentage (SPT-min p < 0.001), as well as significantly higher REM latency (FRL-min p < 0.001), rate in stage shifting (p = 0.005), and number of awakenings/hour (p = 0.002).

Relative to controls, children with EEs also showed significant differences in respiratory parameters (AHI/h p < 0.001, ODI/h p < 0.001, SpO2% p < 0.001, SpO2 nadir% p < 0.001) and a higher rate of periodic limb movements (PLMs% p < 0.001). Our findings suggest that sleep evaluation could be considered mandatory in children with refractory epileptic encephalopathy in order to improve the clinical management and the therapeutic strategies.
epileptic encephalopathy, pediatric polysomnography, sleep-related breathing disorders, sleep obstructive apnea syndrome, periodic limb movements
1525-5050
50-53
Carotenuto, Marco
6bd365b2-5af3-4a6e-a4f8-4c199f7071a6
Parisi, Pasquale
a9ee1126-02e0-41d0-a97a-66d77e8b1173
Esposito, Maria
6c9a1273-de08-41a2-a355-4b8599b4e2aa
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Elia, Maurizio
971a6f54-abc5-4b49-a7e5-0f0502c57e33
Carotenuto, Marco
6bd365b2-5af3-4a6e-a4f8-4c199f7071a6
Parisi, Pasquale
a9ee1126-02e0-41d0-a97a-66d77e8b1173
Esposito, Maria
6c9a1273-de08-41a2-a355-4b8599b4e2aa
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Elia, Maurizio
971a6f54-abc5-4b49-a7e5-0f0502c57e33

Carotenuto, Marco, Parisi, Pasquale, Esposito, Maria, Cortese, Samuele and Elia, Maurizio (2014) Sleep alterations in children with refractory epileptic encephalopathies: a polysomnographic study. Epilepsy & Behavior, 35, 50-53. (doi:10.1016/j.yebeh.2014.03.009).

Record type: Article

Abstract

Data on the relationship between sleep disturbances and refractory epileptic encephalopathies (EEs) are scarce. Our aim was to assess, by means of nocturnal polysomnography, if children with EEs present with objective alterations in sleep organization. Twenty-three children with EEs (12 males; mean age: 8.7 ± 1.4 years) and 40 healthy controls (22 males; mean age: 8.8 ± 1.1 years) underwent an overnight full polysomnography (PSG). Relative to controls, children with EEs showed a significant reduction in all PSG parameters related to sleep duration time in bed (TIB-min p < 0.001), total sleep time (TST-min p < 0.001), and sleep percentage (SPT-min p < 0.001), as well as significantly higher REM latency (FRL-min p < 0.001), rate in stage shifting (p = 0.005), and number of awakenings/hour (p = 0.002).

Relative to controls, children with EEs also showed significant differences in respiratory parameters (AHI/h p < 0.001, ODI/h p < 0.001, SpO2% p < 0.001, SpO2 nadir% p < 0.001) and a higher rate of periodic limb movements (PLMs% p < 0.001). Our findings suggest that sleep evaluation could be considered mandatory in children with refractory epileptic encephalopathy in order to improve the clinical management and the therapeutic strategies.

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More information

Accepted/In Press date: 10 March 2014
e-pub ahead of print date: 4 May 2014
Published date: June 2014
Keywords: epileptic encephalopathy, pediatric polysomnography, sleep-related breathing disorders, sleep obstructive apnea syndrome, periodic limb movements
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 380163
URI: https://eprints.soton.ac.uk/id/eprint/380163
ISSN: 1525-5050
PURE UUID: 349de614-2791-40d2-8ccb-a628e05262b9
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 19 Aug 2015 16:40
Last modified: 17 Sep 2019 00:37

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Contributors

Author: Marco Carotenuto
Author: Pasquale Parisi
Author: Maria Esposito
Author: Samuele Cortese ORCID iD
Author: Maurizio Elia

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