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Long-term efficacy of methylphenidate immediate-release for the treatment of childhood ADHD: a systematic review and meta-analysis

Long-term efficacy of methylphenidate immediate-release for the treatment of childhood ADHD: a systematic review and meta-analysis
Long-term efficacy of methylphenidate immediate-release for the treatment of childhood ADHD: a systematic review and meta-analysis
Objective: To evaluate the long-term effects of methylphenidate imediate-release (MPH-IR), and to confirm the efficacy established in previous meta-analyses of short-term studies. Method: Published and unpublished studies in which participants were treated with MPH-IR for 12 weeks or more were searched. Pooled effect sizes from these studies were computed with the DerSimonian and Laird random-effect model. Meta-regression analysis was conducted to estimate covariates associated with treatment effects. Results: Seven studies were included. Pooled parents ratings for inattention and hyperactivity/impulsivity resulted in standardized mean difference (SMD) = 0.96 (95% confidence interval [CI] = [0.60, 1.32]) and SMD = 1.12 (95% CI = [0.85, 1.39]), respectively; pooled teachers ratings showed SMD = 0.98 (95% CI = [0.09, 1.86]) for inattention and SMD = 1.25 (95% CI = [0.7, 1.81]) for hyperactivity/impulsivity. No evidence of association of any covariates with treatment effect was detected in the meta-regression. Conclusion: MPH-IR is efficacious for childhood ADHD for periods longer than 12 weeks.
ADHD, methylphenidate, meta-analysis, review
1087-0547
Maia, C. R. M.
b3bc57bb-4101-46be-8705-21c768a1f512
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
Caye, A.
8fce7179-6907-43a5-ba78-9743d60e0bbe
Deakin, T. K.
373f7a5e-8f97-4d52-aee7-73297d2d2d89
Polanczyk, G. V.
0efd6183-93d5-4c09-ac95-1303a2710af4
Polanczyk, C. A.
bc4d22a3-5cff-4387-8429-1a9f72e53dfb
Rohde, L. A. P.
ebbede02-9d8d-4405-8072-76f95566e53c
Maia, C. R. M.
b3bc57bb-4101-46be-8705-21c768a1f512
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
Caye, A.
8fce7179-6907-43a5-ba78-9743d60e0bbe
Deakin, T. K.
373f7a5e-8f97-4d52-aee7-73297d2d2d89
Polanczyk, G. V.
0efd6183-93d5-4c09-ac95-1303a2710af4
Polanczyk, C. A.
bc4d22a3-5cff-4387-8429-1a9f72e53dfb
Rohde, L. A. P.
ebbede02-9d8d-4405-8072-76f95566e53c

Maia, C. R. M., Cortese, S., Caye, A., Deakin, T. K., Polanczyk, G. V., Polanczyk, C. A. and Rohde, L. A. P. (2014) Long-term efficacy of methylphenidate immediate-release for the treatment of childhood ADHD: a systematic review and meta-analysis. Journal of Attention Disorders. (doi:10.1177/1087054714559643).

Record type: Article

Abstract

Objective: To evaluate the long-term effects of methylphenidate imediate-release (MPH-IR), and to confirm the efficacy established in previous meta-analyses of short-term studies. Method: Published and unpublished studies in which participants were treated with MPH-IR for 12 weeks or more were searched. Pooled effect sizes from these studies were computed with the DerSimonian and Laird random-effect model. Meta-regression analysis was conducted to estimate covariates associated with treatment effects. Results: Seven studies were included. Pooled parents ratings for inattention and hyperactivity/impulsivity resulted in standardized mean difference (SMD) = 0.96 (95% confidence interval [CI] = [0.60, 1.32]) and SMD = 1.12 (95% CI = [0.85, 1.39]), respectively; pooled teachers ratings showed SMD = 0.98 (95% CI = [0.09, 1.86]) for inattention and SMD = 1.25 (95% CI = [0.7, 1.81]) for hyperactivity/impulsivity. No evidence of association of any covariates with treatment effect was detected in the meta-regression. Conclusion: MPH-IR is efficacious for childhood ADHD for periods longer than 12 weeks.

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e-pub ahead of print date: 10 December 2014
Keywords: ADHD, methylphenidate, meta-analysis, review
Organisations: Clinical Neuroscience

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Local EPrints ID: 380167
URI: https://eprints.soton.ac.uk/id/eprint/380167
ISSN: 1087-0547
PURE UUID: 95bc6a48-34b4-4192-a8d7-82933c01a88f
ORCID for S. Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 20 Aug 2015 13:36
Last modified: 17 Sep 2019 00:37

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Contributors

Author: C. R. M. Maia
Author: S. Cortese ORCID iD
Author: A. Caye
Author: T. K. Deakin
Author: G. V. Polanczyk
Author: C. A. Polanczyk
Author: L. A. P. Rohde

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