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Does restless legs syndrome increase cardiovascular risk in attention-deficit/hyperactivity disorder?

Does restless legs syndrome increase cardiovascular risk in attention-deficit/hyperactivity disorder?
Does restless legs syndrome increase cardiovascular risk in attention-deficit/hyperactivity disorder?
Preliminary evidence suggests a possible association between Attention-Deficit/Hyperactivity Disorder and Restless Legs Syndrome with or without Periodic Limb Movements during Sleep. When comorbid, Restless Legs Syndrome/Periodic Limb Movements during Sleep might aggravate Attention-Deficit/Hyperactivity Disorder symptoms. Pharmacological treatment of Attention-Deficit/Hyperactivity Disorder may be associated, at least in some cases, with adverse cardiovascular events, including clinically significant elevation in heart rate and systemic blood pressure. However, the characteristics of patients with Attention-Deficit/Hyperactivity Disorder at risk for cardiovascular events during pharmacological treatment are poorly understood. Here, we hypothesize that Restless Legs Syndrome and/or Periodic Limb Movements during Sleep comorbid with Attention-Deficit/Hyperactivity Disorder increase cardiovascular risk via imbalance in activity of the autonomic nervous system. Such an imbalance of the could be related to alterations of sleep microarchitecture also detected by cyclic alternating pattern analysis. If empirical studies confirm our hypothesis, the clinician would be advised to systematically screen for and effectively treat Restless Legs Syndrome/Periodic Limb Movements during Sleep even before starting treatment with Attention-Deficit/Hyperactivity Disorder drugs. The management of Restless Legs Syndrome/Periodic Limb Movements during Sleep might reduce cardiovascular risk during pharmacological treatment of Attention-Deficit/Hyperactivity Disorder.
0306-9877
39-42
Angriman, Marco
3520e752-d35c-461f-80f4-b31203319cef
Bruni, Oliviero
b25e21c1-672b-48cb-990e-b907ecf12546
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Angriman, Marco
3520e752-d35c-461f-80f4-b31203319cef
Bruni, Oliviero
b25e21c1-672b-48cb-990e-b907ecf12546
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb

Angriman, Marco, Bruni, Oliviero and Cortese, Samuele (2013) Does restless legs syndrome increase cardiovascular risk in attention-deficit/hyperactivity disorder? Medical Hypotheses, 80 (1), 39-42. (doi:10.1016/j.mehy.2012.10.004).

Record type: Article

Abstract

Preliminary evidence suggests a possible association between Attention-Deficit/Hyperactivity Disorder and Restless Legs Syndrome with or without Periodic Limb Movements during Sleep. When comorbid, Restless Legs Syndrome/Periodic Limb Movements during Sleep might aggravate Attention-Deficit/Hyperactivity Disorder symptoms. Pharmacological treatment of Attention-Deficit/Hyperactivity Disorder may be associated, at least in some cases, with adverse cardiovascular events, including clinically significant elevation in heart rate and systemic blood pressure. However, the characteristics of patients with Attention-Deficit/Hyperactivity Disorder at risk for cardiovascular events during pharmacological treatment are poorly understood. Here, we hypothesize that Restless Legs Syndrome and/or Periodic Limb Movements during Sleep comorbid with Attention-Deficit/Hyperactivity Disorder increase cardiovascular risk via imbalance in activity of the autonomic nervous system. Such an imbalance of the could be related to alterations of sleep microarchitecture also detected by cyclic alternating pattern analysis. If empirical studies confirm our hypothesis, the clinician would be advised to systematically screen for and effectively treat Restless Legs Syndrome/Periodic Limb Movements during Sleep even before starting treatment with Attention-Deficit/Hyperactivity Disorder drugs. The management of Restless Legs Syndrome/Periodic Limb Movements during Sleep might reduce cardiovascular risk during pharmacological treatment of Attention-Deficit/Hyperactivity Disorder.

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More information

Accepted/In Press date: 5 October 2012
e-pub ahead of print date: 27 October 2012
Published date: January 2013
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 380173
URI: https://eprints.soton.ac.uk/id/eprint/380173
ISSN: 0306-9877
PURE UUID: d16e1ea3-3de6-4f0f-8e2e-0f9796787f22
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 20 Aug 2015 15:49
Last modified: 06 Jun 2018 12:21

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