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The sleep macroarchitecture of children at risk for depression recruited in sleep centers

Bat-Pitault, F., Da Fonseca, D., Cortese, S., Le Strat, Y., Kocher, L., Rey, M., Adrien, J., Deruelle, C. and Franco, P. (2013) The sleep macroarchitecture of children at risk for depression recruited in sleep centers European Psychiatry, 28, (3), pp. 168-173.

Record type: Article

Abstract

Objective
The primary aim of this study was to compare the sleep macroarchitecture of children and adolescents whose mothers have a history of depression with children and adolescents whose mothers do not.

Method
Polysomnography (PSG) and Holter electroencephalogram (EEG) were used to compare the sleep architecture of 35 children whose mothers had at least one previous depressive episode (19 boys, aged 4–18 years, “high-risk” group) and 25 controls (13 males, aged 4–18 years, “low-risk” group) whose mothers had never had a depressive episode. The total sleep time, wakefulness after sleep onset (WASO), sleep latency, sleep efficiency, number of awakenings per hour of sleep, percentages of time spent in each sleep stage, rapid eye movement (REM) latency and the depressive symptoms of participants were measured.

Results
In children (4–12 years old), the high-risk group exhibited significantly more depressive symptoms than controls (P = 0.02). However, PSG parameters were not significantly different between high-risk children and controls. In adolescents (13–18 years old), the high-risk subjects presented with significantly more depressive symptoms (P = 0.003), a significant increase in WASO (P = 0.019) and a significant decrease in sleep efficiency compared to controls (P = 0.009).

Conclusion
This study shows that children and adolescents born from mothers with a history of at least one depressive episode had significantly more depressive symptoms than controls. However, only high-risk adolescents presented with concurrent alterations of sleep macroarchitecture.

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More information

Accepted/In Press date: 27 February 2012
e-pub ahead of print date: 30 April 2012
Published date: March 2013
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 380175
URI: http://eprints.soton.ac.uk/id/eprint/380175
ISSN: 0924-9338
PURE UUID: b91c6c22-edae-43c3-850b-3ffb9abf78ee
ORCID for S. Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 20 Aug 2015 15:34
Last modified: 15 Oct 2017 10:13

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Contributors

Author: F. Bat-Pitault
Author: D. Da Fonseca
Author: S. Cortese ORCID iD
Author: Y. Le Strat
Author: L. Kocher
Author: M. Rey
Author: J. Adrien
Author: C. Deruelle
Author: P. Franco

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