Iron and ADHD: time to move beyond serum ferritin levels
Iron and ADHD: time to move beyond serum ferritin levels
Objective: (a) To compare serum ferritin levels in a sample of stimulant-naïve children with ADHD and matched controls and (b) to assess the association of serum ferritin to ADHD symptoms severity, ADHD subtypes, and IQ. Method: The ADHD and the control groups included 101 and 93 children, respectively. Serum ferritin levels were determined with the enzyme-linked immunosorbent assay method. Results: Serum ferritin did not significantly differ between children with ADHD and controls, as well as among ADHD subtypes. Correlations between serum ferritin levels and measures related to IQ or ADHD severity were not significant. Conclusion: This is the largest controlled study that assessed ferritin levels in stimulant-naïve ADHD children. The findings of this study do not support a significant relationship between serum ferritin levels and ADHD. However, the authors’ results based on peripheral measures of iron do not rule out a possible implication of brain iron deficiency in ADHD, grounded on neurobiological hypotheses and preliminary empirical evidence.
ADHD, iron, ferritin
347-357
Donfrancesco, R.
60357c85-a1b0-4ecd-89ab-d7e74396991a
Parisi, P.
63895ce6-8068-4902-a62d-f6a74d3502c6
Vanacore, N.
d3b979e1-3b2d-485f-af34-619bfbdae9a5
Martines, F.
f612e6c5-f1e8-4809-b230-b2c01806c117
Sargentini, V.
0ec77885-dc02-4f35-bcdd-f59bde4bbdd1
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
May 2013
Donfrancesco, R.
60357c85-a1b0-4ecd-89ab-d7e74396991a
Parisi, P.
63895ce6-8068-4902-a62d-f6a74d3502c6
Vanacore, N.
d3b979e1-3b2d-485f-af34-619bfbdae9a5
Martines, F.
f612e6c5-f1e8-4809-b230-b2c01806c117
Sargentini, V.
0ec77885-dc02-4f35-bcdd-f59bde4bbdd1
Cortese, S.
53d4bf2c-4e0e-4c77-9385-218350560fdb
Donfrancesco, R., Parisi, P., Vanacore, N., Martines, F., Sargentini, V. and Cortese, S.
(2013)
Iron and ADHD: time to move beyond serum ferritin levels.
Journal of Attention Disorders, 17 (4), .
(doi:10.1177/1087054711430712).
Abstract
Objective: (a) To compare serum ferritin levels in a sample of stimulant-naïve children with ADHD and matched controls and (b) to assess the association of serum ferritin to ADHD symptoms severity, ADHD subtypes, and IQ. Method: The ADHD and the control groups included 101 and 93 children, respectively. Serum ferritin levels were determined with the enzyme-linked immunosorbent assay method. Results: Serum ferritin did not significantly differ between children with ADHD and controls, as well as among ADHD subtypes. Correlations between serum ferritin levels and measures related to IQ or ADHD severity were not significant. Conclusion: This is the largest controlled study that assessed ferritin levels in stimulant-naïve ADHD children. The findings of this study do not support a significant relationship between serum ferritin levels and ADHD. However, the authors’ results based on peripheral measures of iron do not rule out a possible implication of brain iron deficiency in ADHD, grounded on neurobiological hypotheses and preliminary empirical evidence.
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e-pub ahead of print date: 30 January 2012
Published date: May 2013
Keywords:
ADHD, iron, ferritin
Organisations:
Clinical Neuroscience
Identifiers
Local EPrints ID: 380187
URI: http://eprints.soton.ac.uk/id/eprint/380187
ISSN: 1087-0547
PURE UUID: bc6c9cea-4b69-4733-a9ad-4e175ce5d157
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Date deposited: 21 Aug 2015 13:03
Last modified: 15 Mar 2024 03:52
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Contributors
Author:
R. Donfrancesco
Author:
P. Parisi
Author:
N. Vanacore
Author:
F. Martines
Author:
V. Sargentini
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