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Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians

Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians
Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians
The neuroimaging literature on attention-deficit/hyperactivity disorder (ADHD) is growing rapidly. Here, we provide a critical overview of neuroimaging studies published recently, highlighting perspectives that may be of relevance for clinicians. After a comprehensive search of PubMed, Ovid, Web of Science, and EMBASE, we located 41 pertinent papers published between January 2011 and April 2012, comprising both structural and functional neuroimaging studies. This literature is increasingly contributing to the notion that the pathophysiology of ADHD reflects abnormal interplay among large-scale brain circuits. Moreover, recent studies have begun to reveal the mechanisms of action of pharmacological treatment. Finally, imaging studies with a developmental perspective are revealing the brain correlates of ADHD over the lifespan, complementing clinical observations on the phenotypic continuity and discontinuity of the disorder. However, despite the increasing potential to eventually inform clinical practice, current imaging studies do not have validated applications in day-to-day clinical practice. Although novel analytical techniques are likely to accelerate the pace of translational applications, at the present we advise caution regarding inappropriate commercial misuse of imaging techniques in ADHD.
1523-3812
568-578
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Castellanos, F. Xavier
699a8e5d-77f7-41dd-8dba-50f2dece7dd8
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Castellanos, F. Xavier
699a8e5d-77f7-41dd-8dba-50f2dece7dd8

Cortese, Samuele and Castellanos, F. Xavier (2012) Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians Current Psychiatry Reports, 14, (5), pp. 568-578. (doi:10.1007/s11920-012-0310-y).

Record type: Article

Abstract

The neuroimaging literature on attention-deficit/hyperactivity disorder (ADHD) is growing rapidly. Here, we provide a critical overview of neuroimaging studies published recently, highlighting perspectives that may be of relevance for clinicians. After a comprehensive search of PubMed, Ovid, Web of Science, and EMBASE, we located 41 pertinent papers published between January 2011 and April 2012, comprising both structural and functional neuroimaging studies. This literature is increasingly contributing to the notion that the pathophysiology of ADHD reflects abnormal interplay among large-scale brain circuits. Moreover, recent studies have begun to reveal the mechanisms of action of pharmacological treatment. Finally, imaging studies with a developmental perspective are revealing the brain correlates of ADHD over the lifespan, complementing clinical observations on the phenotypic continuity and discontinuity of the disorder. However, despite the increasing potential to eventually inform clinical practice, current imaging studies do not have validated applications in day-to-day clinical practice. Although novel analytical techniques are likely to accelerate the pace of translational applications, at the present we advise caution regarding inappropriate commercial misuse of imaging techniques in ADHD.

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More information

e-pub ahead of print date: 2 August 2012
Published date: October 2012
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 380399
URI: http://eprints.soton.ac.uk/id/eprint/380399
ISSN: 1523-3812
PURE UUID: 7e5d1c2f-615c-45d8-abbc-71e8a439a25b
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 21 Aug 2015 13:33
Last modified: 17 Jul 2017 20:35

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Contributors

Author: Samuele Cortese ORCID iD
Author: F. Xavier Castellanos

University divisions

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