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Psychostimulants for ADHD-like symptoms in individuals with autism spectrum disorders

Cortese, Samuele, Castelnau, Pierre, Morcillo, Carmen, Roux, Sylvie and Bonnet-Brilhault, Frédérique (2012) Psychostimulants for ADHD-like symptoms in individuals with autism spectrum disorders Expert Review of Neurotherapeutics, 12, (4), pp. 461-473. (doi:10.1586/ern.12.23).

Record type: Article


We conducted a comprehensive review of studies assessing the efficacy and tolerability of psychostimulants for ADHD-like symptoms in individuals with autism spectrum disorder (encompassing autism disorder, Asperger’s syndrome and pervasive developmental disorders not otherwise specified). PubMed, Ovid, EMBASE, Web of Science, ERIC and CINHAL were searched through 3 January 2012. From a pool of 348 potentially relevant references, 12 citations (11 studies) were retained as pertinent. Four of the included studies had a randomized controlled design. Most of the studies assessed methylphenidate immediate release. Despite inter-study heterogeneity, taken together, the results of the selected reports suggest that psychostimulants may be effective for ADHD-like symptoms in autism spectrum disorder individuals. The most common adverse events reported in the included trials were appetite reduction, sleep-onset difficulties, irritability and emotional outbursts. We discuss future directions in the field, including the need for trials assessing more ecological outcomes and combined treatment strategies tailored to the specific individual features.

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e-pub ahead of print date: 1 April 2012
Keywords: attention-deficit/hyperactivity disorder, autism, autism spectrum disorders, hyperactivity, inattention, methylphenidate, pervasive developmental disorders, pharmacological treatment, psychostimulants
Organisations: Clinical Neuroscience


Local EPrints ID: 380406
ISSN: 1473-7175
PURE UUID: a8ff3280-e758-4c56-a7cf-9ab13aba71b1
ORCID for Samuele Cortese: ORCID iD

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Date deposited: 21 Aug 2015 13:36
Last modified: 17 Jul 2017 20:35

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Author: Samuele Cortese ORCID iD
Author: Pierre Castelnau
Author: Carmen Morcillo
Author: Sylvie Roux
Author: Frédérique Bonnet-Brilhault

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