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Effectiveness of ropinirole for RLS and depressive symptoms in an 11-year-old girl

Effectiveness of ropinirole for RLS and depressive symptoms in an 11-year-old girl
Effectiveness of ropinirole for RLS and depressive symptoms in an 11-year-old girl
An 11-year-old girl was referred for an irresistible urge to move her legs associated with uncomfortable sensations. She was diagnosed with definite Restless Legs Syndrome (RLS) according to 2003 NIH criteria. The IRLSSG severity scale score was 31 (very severe). The girl also presented with dysthymic disorder according to DSM-IV criteria, as confirmed by the semi-structured interview Kiddie-SADS-PL. The score on the Children Depression Inventory (CDI) was in the clinical range (21). The total score on the Sleep Disturbance Scale for Children (SDSC) was 100. A standard PSG revealed a periodic limb movement index of 16.5, indicating that the child also presented with Periodic Limb Movements Disorder. The girl was treated with ropinirole (a D2/D3 dopamine agonist). After 3 months of treatment (0.50 mg/day at 8.00 PM), RLS, as well as depressive symptoms, remarkably improved, as suggested by the improvement in the IRLSSG severity and CDI scores (14 and 4, respectively). No side effects were reported. The total score on the SDSC also improved (73). The PLM index did not remarkably change. We strongly recommend double blind, randomized, controlled studies to gain insight into the effective treatment strategies for RLS and depression when they coexist in children.
RLS, PLMS, depression, ropinirole, iron, childhood
1389-9457
259-261
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Konofal, Eric
6328bf1a-74f1-4438-8c14-333ccc8931eb
Lecendreux, Michel
51135545-1b33-4540-8ba9-1e8a1cc57173
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Konofal, Eric
6328bf1a-74f1-4438-8c14-333ccc8931eb
Lecendreux, Michel
51135545-1b33-4540-8ba9-1e8a1cc57173

Cortese, Samuele, Konofal, Eric and Lecendreux, Michel (2009) Effectiveness of ropinirole for RLS and depressive symptoms in an 11-year-old girl. Sleep Medicine, 10 (2), 259-261. (doi:10.1016/j.sleep.2007.10.023).

Record type: Article

Abstract

An 11-year-old girl was referred for an irresistible urge to move her legs associated with uncomfortable sensations. She was diagnosed with definite Restless Legs Syndrome (RLS) according to 2003 NIH criteria. The IRLSSG severity scale score was 31 (very severe). The girl also presented with dysthymic disorder according to DSM-IV criteria, as confirmed by the semi-structured interview Kiddie-SADS-PL. The score on the Children Depression Inventory (CDI) was in the clinical range (21). The total score on the Sleep Disturbance Scale for Children (SDSC) was 100. A standard PSG revealed a periodic limb movement index of 16.5, indicating that the child also presented with Periodic Limb Movements Disorder. The girl was treated with ropinirole (a D2/D3 dopamine agonist). After 3 months of treatment (0.50 mg/day at 8.00 PM), RLS, as well as depressive symptoms, remarkably improved, as suggested by the improvement in the IRLSSG severity and CDI scores (14 and 4, respectively). No side effects were reported. The total score on the SDSC also improved (73). The PLM index did not remarkably change. We strongly recommend double blind, randomized, controlled studies to gain insight into the effective treatment strategies for RLS and depression when they coexist in children.

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More information

Accepted/In Press date: 18 October 2007
e-pub ahead of print date: 4 March 2008
Published date: 2009
Keywords: RLS, PLMS, depression, ropinirole, iron, childhood
Organisations: Clinical Neuroscience

Identifiers

Local EPrints ID: 380444
URI: http://eprints.soton.ac.uk/id/eprint/380444
ISSN: 1389-9457
PURE UUID: b6b438b4-cc80-4caf-be4b-e2f65a1c02e6
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

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Date deposited: 20 Aug 2015 16:30
Last modified: 17 Dec 2019 01:34

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Contributors

Author: Samuele Cortese ORCID iD
Author: Eric Konofal
Author: Michel Lecendreux

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