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Brief culturally adapted CBT for psychosis (CaCBTp): A randomized controlled trial from a low income country

Brief culturally adapted CBT for psychosis (CaCBTp): A randomized controlled trial from a low income country
Brief culturally adapted CBT for psychosis (CaCBTp): A randomized controlled trial from a low income country
Evidence for the effectiveness of Culturally adapted CBT for psychosis in Low And Middle Income Countries (LAMIC) is limited. Therefore, brief Culturally adapted CBT for psychosis (CaCBTp) targeted at symptoms of schizophrenia for outpatients plus treatment as usual (TAU) is compared with TAU. A total of 116 participants with schizophrenia were recruited from 2 hospitals in Karachi, Pakistan, and randomized into two groups with 1: 1 allocation (CaCBTp plus TAU = 59, TAU = 57). A brief version of CaCBTp (6 individual sessions with the involvement of main carer, plus one session for the family) was provided over 4 months. Psychopathology was measured using Positive and Negative Syndrome Scale of Schizophrenia (PANSS), Psychotic Symptom Rating Scales (PSYRATS), and the Schedule for Assessment of Insight (SAI) at baseline and end of therapy. Participants in treatment group, showed statistically significant improvement in all measures of psychopathology at the end of the study compared with control group. Participants in treatment group showed statistically significant improvement in Positive Symptoms (PANSS, Positive Symptoms Subscale; p = 0.000), Negative Symptoms (PANSS, Negative Symptoms subscales; p = 0.000), Delusions (PSYRATS, Delusions Subscale; p = 0.000), Hallucinations (PSYRATS, Hallucination Subscale; p = 0.000) and Insight (SAI; p = 0.007). The results suggest that brief, Culturally adapted CBT for psychosis can be an effective treatment when provided in combination with TAU, for patients with schizophrenia in a LAMIC setting. This is the first trial of CBT for psychosis from outside the western world. These findings need replicating in other low and middle income countries
schizophrenia, positive and negative symptoms, psychopathology, insight
0920-9964
143-148
Farooq, N.
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Saeed, S.
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Irfanc, M.
c78e88cf-a2fb-4cd5-b89e-30e34176a00e
Kiran, T.
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Mehmood, N.
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Gul, M.
dc9fa18e-1a0e-4d46-b12e-b9f2981d2dfc
Munshi, T.
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Ahmadf, S.
a57df417-ab4d-413b-a2f7-57ad9b240c71
Kazmi, A.
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Husain, N.
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Farooq, S.
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Ayub, M.
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Kingdon, D.
14cdc422-10b4-4b2d-88ec-24fde5f4329b
Farooq, N.
a383328d-5fd1-4b5a-a765-4bd8efb4079d
Saeed, S.
583222d9-d7f8-4ffa-ab1d-95313cec4abe
Irfanc, M.
c78e88cf-a2fb-4cd5-b89e-30e34176a00e
Kiran, T.
27149292-f9eb-43b5-85a5-2f38a41a14e8
Mehmood, N.
28c63a1b-b889-4d06-8223-61920fc52948
Gul, M.
dc9fa18e-1a0e-4d46-b12e-b9f2981d2dfc
Munshi, T.
b32ae956-b064-4621-8760-400ecc6bd923
Ahmadf, S.
a57df417-ab4d-413b-a2f7-57ad9b240c71
Kazmi, A.
0523442a-2e95-475b-b17f-ce32189c49da
Husain, N.
d1f4b40c-d002-483b-a263-01d4bc8b8760
Farooq, S.
67c8a22f-8b0e-4b73-b69b-f892c3d0b355
Ayub, M.
43d8a928-b554-4cf1-aecd-11492b3c8c45
Kingdon, D.
14cdc422-10b4-4b2d-88ec-24fde5f4329b

Farooq, N., Saeed, S., Irfanc, M., Kiran, T., Mehmood, N., Gul, M., Munshi, T., Ahmadf, S., Kazmi, A., Husain, N., Farooq, S., Ayub, M. and Kingdon, D. (2015) Brief culturally adapted CBT for psychosis (CaCBTp): A randomized controlled trial from a low income country. Schizophrenia Research, 164 (1-3), 143-148. (doi:10.1016/j.schres.2015.02.015).

Record type: Article

Abstract

Evidence for the effectiveness of Culturally adapted CBT for psychosis in Low And Middle Income Countries (LAMIC) is limited. Therefore, brief Culturally adapted CBT for psychosis (CaCBTp) targeted at symptoms of schizophrenia for outpatients plus treatment as usual (TAU) is compared with TAU. A total of 116 participants with schizophrenia were recruited from 2 hospitals in Karachi, Pakistan, and randomized into two groups with 1: 1 allocation (CaCBTp plus TAU = 59, TAU = 57). A brief version of CaCBTp (6 individual sessions with the involvement of main carer, plus one session for the family) was provided over 4 months. Psychopathology was measured using Positive and Negative Syndrome Scale of Schizophrenia (PANSS), Psychotic Symptom Rating Scales (PSYRATS), and the Schedule for Assessment of Insight (SAI) at baseline and end of therapy. Participants in treatment group, showed statistically significant improvement in all measures of psychopathology at the end of the study compared with control group. Participants in treatment group showed statistically significant improvement in Positive Symptoms (PANSS, Positive Symptoms Subscale; p = 0.000), Negative Symptoms (PANSS, Negative Symptoms subscales; p = 0.000), Delusions (PSYRATS, Delusions Subscale; p = 0.000), Hallucinations (PSYRATS, Hallucination Subscale; p = 0.000) and Insight (SAI; p = 0.007). The results suggest that brief, Culturally adapted CBT for psychosis can be an effective treatment when provided in combination with TAU, for patients with schizophrenia in a LAMIC setting. This is the first trial of CBT for psychosis from outside the western world. These findings need replicating in other low and middle income countries

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Accepted/In Press date: 21 February 2015
Published date: 8 March 2015
Keywords: schizophrenia, positive and negative symptoms, psychopathology, insight
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 380462
URI: https://eprints.soton.ac.uk/id/eprint/380462
ISSN: 0920-9964
PURE UUID: d1e1f0ae-04c2-41d8-a74b-5d0c2083c6bb

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Date deposited: 10 Sep 2015 12:12
Last modified: 27 Nov 2018 17:31

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Contributors

Author: N. Farooq
Author: S. Saeed
Author: M. Irfanc
Author: T. Kiran
Author: N. Mehmood
Author: M. Gul
Author: T. Munshi
Author: S. Ahmadf
Author: A. Kazmi
Author: N. Husain
Author: S. Farooq
Author: M. Ayub
Author: D. Kingdon

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