Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature

Cortese, Samuele, Konofal, Eric, Lecendreux, Michel, Arnulf, Isabelle, Mouren, Marie-Christine, Darra, Francesca and Dalla Bernardina, Bernardo (2005) Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature. Sleep, 28 (8), 1007-1013. (PMID:16218085)

Abstract

Although still limited, evidence from clinical studies demonstrates an association between RLS and ADHD or ADHD symptoms. Further clinical studies using standard criteria and procedures are needed to better estimate the degree of association. Epidemiologic studies are required to assess the relationship between ADHD and RLS symptoms in nonclinical samples. Further investigations should address the mechanisms underlying the relationship between RLS and ADHD. Several dopaminergic agents seem to be promising treatment for RLS associated with ADHD symptoms. To date, however, the absence of randomized and blinded controlled studies does not allow evidence-based recommendations.

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Contributors

Author: Samuele Cortese

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