Quantifying seasonal population fluxes driving rubella transmission dynamics using mobile phone data

Wesolowski, Amy, Metcalf, C. J. E., Eagle, Nathan, Kombich, Janeth, Grenfell, Bryan T., Bjørnstad, Ottar N., Lessler, Justin, Tatem, Andrew J. and Buckee, Caroline O. (2015) Quantifying seasonal population fluxes driving rubella transmission dynamics using mobile phone data. Proceedings of the National Academy of Sciences, 201423542. (doi:10.1073/pnas.1423542112).

Abstract

Changing patterns of human aggregation are thought to drive annual and multiannual outbreaks of infectious diseases, but the paucity of data about travel behavior and population flux over time has made this idea difficult to test quantitatively. Current measures of human mobility, especially in low-income settings, are often static, relying on approximate travel times, road networks, or cross-sectional surveys. Mobile phone data provide a unique source of information about human travel, but the power of these data to describe epidemiologically relevant changes in population density remains unclear. Here we quantify seasonal travel patterns using mobile phone data from nearly 15 million anonymous subscribers in Kenya. Using a rich data source of rubella incidence, we show that patterns of population travel (fluxes) inferred from mobile phone data are predictive of disease transmission and improve significantly on standard school term time and weather covariates. Further, combining seasonal and spatial data on travel from mobile phone data allows us to characterize seasonal fluctuations in risk across Kenya and produce dynamic importation risk maps for rubella. Mobile phone data therefore offer a valuable previously unidentified source of data for measuring key drivers of seasonal epidemics.

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