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Point-of-care testing for respiratory viruses in adults: The current landscape and future potential

Point-of-care testing for respiratory viruses in adults: The current landscape and future potential
Point-of-care testing for respiratory viruses in adults: The current landscape and future potential
Respiratory viruses are responsible for a large proportion of acute respiratory illness in adults as well as children, and are associated with a huge socio-economic burden worldwide. Development of accurate point-of-care tests (POCT) for respiratory viruses has been listed as a priority by the World Health Organisation and replacing the current paradigm of empirical antimicrobial use with directed use is a listed goal of the movement for reduction in antimicrobial resistance. POCTs for respiratory viruses have previously been limited by the poor sensitivity of antigen detection based tests and by a limited range of detectable viruses. Highly accurate molecular platforms are now able to test for a comprehensive range of viruses, can be operated by non-laboratory staff and can generate a result in approximately 1 h, making them potentially deployable as POCTs. The potential clinical benefits of POC testing for respiratory viruses in adults include a reduction in unnecessary antibiotic use, improved antiviral prescribing for influenza and rationalisation of isolation facilities. We review here the burden of disease, the currently available molecular platforms with potential for POCT use and the existing evidence for clinical and economic benefits of testing for respiratory viruses in adults.
0163-4453
Brendish, Nathan J.
1c73d43e-79fb-4c3a-88bc-08207d3c3ba8
Schiff, Hannah F.
20368eb5-6ffb-434a-be9e-2fd0025860e4
Clark, Tristan W.
712ec18e-613c-45df-a013-c8a22834e14f
Brendish, Nathan J.
1c73d43e-79fb-4c3a-88bc-08207d3c3ba8
Schiff, Hannah F.
20368eb5-6ffb-434a-be9e-2fd0025860e4
Clark, Tristan W.
712ec18e-613c-45df-a013-c8a22834e14f

Brendish, Nathan J., Schiff, Hannah F. and Clark, Tristan W. (2015) Point-of-care testing for respiratory viruses in adults: The current landscape and future potential. Journal of Infection. (doi:10.1016/j.jinf.2015.07.008). (PMID:26215335 )

Record type: Article

Abstract

Respiratory viruses are responsible for a large proportion of acute respiratory illness in adults as well as children, and are associated with a huge socio-economic burden worldwide. Development of accurate point-of-care tests (POCT) for respiratory viruses has been listed as a priority by the World Health Organisation and replacing the current paradigm of empirical antimicrobial use with directed use is a listed goal of the movement for reduction in antimicrobial resistance. POCTs for respiratory viruses have previously been limited by the poor sensitivity of antigen detection based tests and by a limited range of detectable viruses. Highly accurate molecular platforms are now able to test for a comprehensive range of viruses, can be operated by non-laboratory staff and can generate a result in approximately 1 h, making them potentially deployable as POCTs. The potential clinical benefits of POC testing for respiratory viruses in adults include a reduction in unnecessary antibiotic use, improved antiviral prescribing for influenza and rationalisation of isolation facilities. We review here the burden of disease, the currently available molecular platforms with potential for POCT use and the existing evidence for clinical and economic benefits of testing for respiratory viruses in adults.

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More information

Accepted/In Press date: 17 July 2015
e-pub ahead of print date: 26 July 2015
Organisations: NIHR Southampton Respiratory Biomedical Research Unit, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 380569
URI: https://eprints.soton.ac.uk/id/eprint/380569
ISSN: 0163-4453
PURE UUID: 66ebe69e-3a7d-4f8d-ae89-f3158882e5d2
ORCID for Tristan W. Clark: ORCID iD orcid.org/0000-0001-6026-5295

Catalogue record

Date deposited: 03 Sep 2015 13:59
Last modified: 06 Jun 2018 12:23

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Contributors

Author: Nathan J. Brendish
Author: Hannah F. Schiff

University divisions

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