The University of Southampton
University of Southampton Institutional Repository

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Electrodeposited conductive polymers for controlled drug release: polypyrrole
Electrodeposited conductive polymers for controlled drug release: polypyrrole
Over the last 40 years, electrically conductive polymers have become well established as important electrode materials. Polyanilines, polythiophenes and polypyrroles have received particular attention due to their ease of synthesis, chemical stability, mechanical robustness and the ability to tailor their properties. Electrochemical synthesis of these materials as films have proved to be a robust and simple way to realise surface layers with controlled thickness, electrical conductivity and ion transport. In the last decade, the biomedical compatibility of electrodeposited polymers has become recognised; in particular, polypyrroles have been studied extensively and can provide an effective route to pharmaceutical drug release. The factors controlling the electrodeposition of this polymer from practical electrolytes are considered in this review including electrolyte composition and operating conditions such as the temperature and electrode potential. Voltammetry and current-time behaviour are seen to be effective techniques for film characterisation during and after their formation. The degree of take-up and the rate of drug release depend greatly on the structure, composition and oxidation state of the polymer film. Specialised aspects are considered, including galvanic cells with a Mg anode, use of catalytic nanomotors or implantable biofuel cells for a self-powered drug delivery system and nanoporous surfaces and nanostructures. Following a survey of polymer and drug types, progress in this field is summarised and aspects requiring further research are highlighted
conducting polymer, electroactive, drug delivery, nanocomposites
1432-8488
1-21
Alshammary, Badr
e32e4e92-e5d5-4135-8655-7e287bf81759
Walsh, Frank C.
309528e7-062e-439b-af40-9309bc91efb2
Herrasti, Pilar
e16836cf-f610-4ba6-9077-a1f8b31eab3d
Ponce de Leon, Carlos
508a312e-75ff-4bcb-9151-dacc424d755c
Alshammary, Badr
e32e4e92-e5d5-4135-8655-7e287bf81759
Walsh, Frank C.
309528e7-062e-439b-af40-9309bc91efb2
Herrasti, Pilar
e16836cf-f610-4ba6-9077-a1f8b31eab3d
Ponce de Leon, Carlos
508a312e-75ff-4bcb-9151-dacc424d755c

Alshammary, Badr, Walsh, Frank C., Herrasti, Pilar and Ponce de Leon, Carlos (2015) Electrodeposited conductive polymers for controlled drug release: polypyrrole. Journal of Solid State Electrochemistry, 1-21. (doi:10.1007/s10008-015-2982-9).

Record type: Article

Abstract

Over the last 40 years, electrically conductive polymers have become well established as important electrode materials. Polyanilines, polythiophenes and polypyrroles have received particular attention due to their ease of synthesis, chemical stability, mechanical robustness and the ability to tailor their properties. Electrochemical synthesis of these materials as films have proved to be a robust and simple way to realise surface layers with controlled thickness, electrical conductivity and ion transport. In the last decade, the biomedical compatibility of electrodeposited polymers has become recognised; in particular, polypyrroles have been studied extensively and can provide an effective route to pharmaceutical drug release. The factors controlling the electrodeposition of this polymer from practical electrolytes are considered in this review including electrolyte composition and operating conditions such as the temperature and electrode potential. Voltammetry and current-time behaviour are seen to be effective techniques for film characterisation during and after their formation. The degree of take-up and the rate of drug release depend greatly on the structure, composition and oxidation state of the polymer film. Specialised aspects are considered, including galvanic cells with a Mg anode, use of catalytic nanomotors or implantable biofuel cells for a self-powered drug delivery system and nanoporous surfaces and nanostructures. Following a survey of polymer and drug types, progress in this field is summarised and aspects requiring further research are highlighted

Text
__soton.ac.uk_ude_PersonalFiles_Users_capla_mydocuments_Papers own and group_Electrodeposited conductive polymers for controlled drug release- polypyrrole.pdf - Accepted Manuscript
Download (1MB)

More information

Accepted/In Press date: 20 July 2015
Published date: 8 August 2015
Keywords: conducting polymer, electroactive, drug delivery, nanocomposites
Organisations: Energy Technology Group

Identifiers

Local EPrints ID: 380669
URI: http://eprints.soton.ac.uk/id/eprint/380669
ISSN: 1432-8488
PURE UUID: 76cc21a3-0ed8-4b77-8dca-dbe945383c96
ORCID for Carlos Ponce de Leon: ORCID iD orcid.org/0000-0002-1907-5913

Catalogue record

Date deposited: 14 Sep 2015 10:14
Last modified: 17 Dec 2019 01:46

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×