Gallstone disease and increased risk of ischemic heart disease: causal association or epiphenomenon?
Gallstone disease and increased risk of ischemic heart disease: causal association or epiphenomenon?
Gallstone disease (GD) is a major health problem in developed societies, affecting up to 15% of the general
population.1 Although many risk factors for gallstone formation are not modifiable; obesity, diabetes,
metabolic syndrome, rapid weight loss and a sedentary lifestyle are risk factors for GD that can be
changed.1 Moreover, the chronic use of some drugs (e.g., octreotide, thiazide diuretics and some oral
contraceptives) may also increase the risk of developing GD.1 In contrast, long-term statin use seems to
prevent gallstone formation, possibly by decreasing biliary cholesterol secretion and saturation and
inhibition of cholesterol crystal formation.1,2 The rising pandemic of obesity and the metabolic syndrome is
likely to lead to an increase in the prevalence of gallstones in many parts of the world in the foreseeable
future.
2073-2075
Targher, G.
5a842bd2-91c4-4063-b639-da6c681f3698
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
October 2015
Targher, G.
5a842bd2-91c4-4063-b639-da6c681f3698
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, G. and Byrne, Christopher D.
(2015)
Gallstone disease and increased risk of ischemic heart disease: causal association or epiphenomenon?
[in special issue: Gallstone Disease and the Risk of Ischemic]
Arteriosclerosis, Thrombosis, and Vascular Biology, 35 (10), .
(PMID:26399917)
Abstract
Gallstone disease (GD) is a major health problem in developed societies, affecting up to 15% of the general
population.1 Although many risk factors for gallstone formation are not modifiable; obesity, diabetes,
metabolic syndrome, rapid weight loss and a sedentary lifestyle are risk factors for GD that can be
changed.1 Moreover, the chronic use of some drugs (e.g., octreotide, thiazide diuretics and some oral
contraceptives) may also increase the risk of developing GD.1 In contrast, long-term statin use seems to
prevent gallstone formation, possibly by decreasing biliary cholesterol secretion and saturation and
inhibition of cholesterol crystal formation.1,2 The rising pandemic of obesity and the metabolic syndrome is
likely to lead to an increase in the prevalence of gallstones in many parts of the world in the foreseeable
future.
Text
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Accepted/In Press date: 18 August 2015
Published date: October 2015
Organisations:
Human Development & Health
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Local EPrints ID: 380674
URI: http://eprints.soton.ac.uk/id/eprint/380674
ISSN: 1079-5642
PURE UUID: b89ef43d-af28-4930-97e9-07c253580b76
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Date deposited: 17 Sep 2015 10:56
Last modified: 15 Mar 2024 03:02
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Author:
G. Targher
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