Neisseria meningitidis serogroup B bivalent factor H binding protein vaccine
Neisseria meningitidis serogroup B bivalent factor H binding protein vaccine
With the successful development of meningococcal vaccines against other serogroups, disease caused by Neisseria meningitidis serogroup B now accounts for a disproportionate frequency compared with other serogroups, particularly in the US and Europe. Infants and adolescents bear the highest incidence of disease, which typically manifests as meningitis and septicemia. This vaccine profile article examines a bivalent factor H binding protein (fHbp; also known as LP2086) vaccine that has now been approved by the US FDA for use in 10- to 25-year olds. The manufacturer has shelved plans for further investigation of its use in infants because of high rates of fever in Phase I and II trials in that age group.
fHbp, MenB vaccine, meningococcal vaccine, rLP2086, Trumenba
493-503
Brendish, Nathan J
27ebd617-d0f0-4d6d-a666-429fae48d795
Read, Robert C
b5caca7b-0063-438a-b703-7ecbb6fc2b51
14 April 2015
Brendish, Nathan J
27ebd617-d0f0-4d6d-a666-429fae48d795
Read, Robert C
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Abstract
With the successful development of meningococcal vaccines against other serogroups, disease caused by Neisseria meningitidis serogroup B now accounts for a disproportionate frequency compared with other serogroups, particularly in the US and Europe. Infants and adolescents bear the highest incidence of disease, which typically manifests as meningitis and septicemia. This vaccine profile article examines a bivalent factor H binding protein (fHbp; also known as LP2086) vaccine that has now been approved by the US FDA for use in 10- to 25-year olds. The manufacturer has shelved plans for further investigation of its use in infants because of high rates of fever in Phase I and II trials in that age group.
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e-pub ahead of print date: 23 February 2015
Published date: 14 April 2015
Keywords:
fHbp, MenB vaccine, meningococcal vaccine, rLP2086, Trumenba
Organisations:
NIHR Southampton Respiratory Biomedical Research Unit, Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 380715
URI: http://eprints.soton.ac.uk/id/eprint/380715
ISSN: 1476-0584
PURE UUID: 8929d1a7-e64b-4555-b437-8d104a147925
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Date deposited: 03 Sep 2015 13:53
Last modified: 15 Mar 2024 03:42
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Author:
Nathan J Brendish
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