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Nasopharyngeal bacterial carriage in the conjugate vaccine era with a focus on pneumococci

Nasopharyngeal bacterial carriage in the conjugate vaccine era with a focus on pneumococci
Nasopharyngeal bacterial carriage in the conjugate vaccine era with a focus on pneumococci
Seven-valent pneumococcal conjugate vaccine (PCV7) was included in the UK national immunisation program in 2006, and this was replaced by thirteen-valent PCV in 2010. During this time, the carriage of vaccine-type Streptococcus pneumoniae decreased but pneumococcal carriage remained stable due to increases in non-vaccine-type S. pneumoniae. Carriage studies have been undertaken in various countries to monitor vaccine-type replacement and to help predict the serotypes, which may cause invasive disease. There has been less focus on how conjugate vaccines indirectly affect colonization of other nasopharyngeal bacteria. If the nasopharynx is treated as a niche, then bacterial dynamics are accepted to occur. Alterations in these dynamics have been shown due to seasonal changes, antibiotic use, and sibling/day care interaction. It has been shown that, following PCV7 introduction, an eradication of pneumococcal vaccine types has resulted in increases in the abundance of other respiratory pathogens including Haemophilus influenzae and Staphylococcus aureus. These changes are difficult to attribute to PCV7 introduction alone and these studies do not account for further changes due to PCV13 implementation. This review aims to describe nasopharyngeal cocarriage of respiratory pathogens in the PCV era.
2314-8861
Devine, V.T.
ce4845c0-7013-4e4f-9f57-e1616cc96e98
Jefferies, Johanna M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Devine, V.T.
ce4845c0-7013-4e4f-9f57-e1616cc96e98
Jefferies, Johanna M.C.
9468e292-0b41-412d-9470-944e257c7bcf
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1

Devine, V.T., Jefferies, Johanna M.C., Clarke, Stuart C. and Faust, S.N. (2015) Nasopharyngeal bacterial carriage in the conjugate vaccine era with a focus on pneumococci. Journal of Immunology Research. (doi:10.1155/2015/394368).

Record type: Article

Abstract

Seven-valent pneumococcal conjugate vaccine (PCV7) was included in the UK national immunisation program in 2006, and this was replaced by thirteen-valent PCV in 2010. During this time, the carriage of vaccine-type Streptococcus pneumoniae decreased but pneumococcal carriage remained stable due to increases in non-vaccine-type S. pneumoniae. Carriage studies have been undertaken in various countries to monitor vaccine-type replacement and to help predict the serotypes, which may cause invasive disease. There has been less focus on how conjugate vaccines indirectly affect colonization of other nasopharyngeal bacteria. If the nasopharynx is treated as a niche, then bacterial dynamics are accepted to occur. Alterations in these dynamics have been shown due to seasonal changes, antibiotic use, and sibling/day care interaction. It has been shown that, following PCV7 introduction, an eradication of pneumococcal vaccine types has resulted in increases in the abundance of other respiratory pathogens including Haemophilus influenzae and Staphylococcus aureus. These changes are difficult to attribute to PCV7 introduction alone and these studies do not account for further changes due to PCV13 implementation. This review aims to describe nasopharyngeal cocarriage of respiratory pathogens in the PCV era.

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More information

e-pub ahead of print date: 10 June 2015
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 380771
URI: http://eprints.soton.ac.uk/id/eprint/380771
ISSN: 2314-8861
PURE UUID: c3a4d355-fd4a-4641-8755-906fbb64b76a
ORCID for Stuart C. Clarke: ORCID iD orcid.org/0000-0002-7009-1548
ORCID for S.N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

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Date deposited: 17 Sep 2015 13:00
Last modified: 18 Feb 2021 17:08

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Contributors

Author: V.T. Devine
Author: Johanna M.C. Jefferies
Author: S.N. Faust ORCID iD

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