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Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors

Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors
Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors
Our results show that PBECs from asthmatic donors are more susceptible to CSE-induced apoptosis. This response involves AIF, which has been implicated in DNA damage and ROS-mediated cell-death. Epithelial susceptibility to CSE may contribute to the impact of environmental tobacco smoke in asthma
1932-6203
e0120510
Bucchieri, Fabio
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Marino Gammazza, Antonella
b8683acd-7d10-4e5a-9224-ff7b283d7a65
Pitruzzella, Alessandro
378be3bd-b7fc-4615-bd90-7a3753077a46
Fucarino, Alberto
95c722bb-5f4d-43b7-a173-c72e40b3c792
Farina, Felicia
8c33c6f6-dcb0-46f7-9907-9444a19b4f8b
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Holgate, Stephen T
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Zummo, Giovanni
54897ebe-00d6-47b9-9914-fb350deb7b14
Davies, Donna E
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Bucchieri, Fabio
3f85c9c8-2bc0-4fd0-b481-a03935fe3cb0
Marino Gammazza, Antonella
b8683acd-7d10-4e5a-9224-ff7b283d7a65
Pitruzzella, Alessandro
378be3bd-b7fc-4615-bd90-7a3753077a46
Fucarino, Alberto
95c722bb-5f4d-43b7-a173-c72e40b3c792
Farina, Felicia
8c33c6f6-dcb0-46f7-9907-9444a19b4f8b
Howarth, Peter
ff19c8c4-86b0-4a88-8f76-b3d87f142a21
Holgate, Stephen T
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Zummo, Giovanni
54897ebe-00d6-47b9-9914-fb350deb7b14
Davies, Donna E
7de8fdc7-3640-4e3a-aa91-d0e03f990c38

Bucchieri, Fabio, Marino Gammazza, Antonella, Pitruzzella, Alessandro, Fucarino, Alberto, Farina, Felicia, Howarth, Peter, Holgate, Stephen T, Zummo, Giovanni and Davies, Donna E (2015) Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors. PLoS ONE, 10 (3), e0120510. (doi:10.1371/journal.pone.012051). (PMID:25793769)

Record type: Article

Abstract

Our results show that PBECs from asthmatic donors are more susceptible to CSE-induced apoptosis. This response involves AIF, which has been implicated in DNA damage and ROS-mediated cell-death. Epithelial susceptibility to CSE may contribute to the impact of environmental tobacco smoke in asthma

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Accepted/In Press date: 23 January 2015
Published date: 20 March 2015
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 380775
URI: http://eprints.soton.ac.uk/id/eprint/380775
DOI: doi:10.1371/journal.pone.012051
ISSN: 1932-6203
PURE UUID: bc1d4494-f776-412b-8b7d-805398d54e36
ORCID for Donna E Davies: ORCID iD orcid.org/0000-0002-5117-2991

Catalogue record

Date deposited: 14 Sep 2015 12:53
Last modified: 15 Mar 2024 02:35

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Contributors

Author: Fabio Bucchieri
Author: Antonella Marino Gammazza
Author: Alessandro Pitruzzella
Author: Alberto Fucarino
Author: Felicia Farina
Author: Peter Howarth
Author: Stephen T Holgate
Author: Giovanni Zummo
Author: Donna E Davies ORCID iD

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