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Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model

Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model
Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model
Th2 cytokines increase release of inflammatory cytokines in the presence of rhinovirus infection. This increase is independent of effects of virus replication. Inhibition of the PI3K pathway inhibits IP-10 expression.
1932-6203
e94010-[7pp]
Cakebread, Julie A.
f5aa15da-3462-4809-9e69-eef5d6d2df0d
Haitchi, Hans Michael
68dadb29-305d-4236-884f-e9c93f4d78fe
Xu, Yunhe
cfbd92dd-a51a-4b9a-946e-720f5eeadfa4
Holgate, Stephen T
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Davies, Donna E
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Cakebread, Julie A.
f5aa15da-3462-4809-9e69-eef5d6d2df0d
Haitchi, Hans Michael
68dadb29-305d-4236-884f-e9c93f4d78fe
Xu, Yunhe
cfbd92dd-a51a-4b9a-946e-720f5eeadfa4
Holgate, Stephen T
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Davies, Donna E
7de8fdc7-3640-4e3a-aa91-d0e03f990c38

Cakebread, Julie A., Haitchi, Hans Michael, Xu, Yunhe, Holgate, Stephen T, Roberts, Graham and Davies, Donna E (2014) Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model. PLoS ONE, 9 (4), e94010-[7pp]. (doi:10.1371/journal.pone.0094010). (PMID:24705919)

Record type: Article

Abstract

Th2 cytokines increase release of inflammatory cytokines in the presence of rhinovirus infection. This increase is independent of effects of virus replication. Inhibition of the PI3K pathway inhibits IP-10 expression.

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Accepted/In Press date: 12 March 2014
Published date: 4 April 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 380874
URI: http://eprints.soton.ac.uk/id/eprint/380874
DOI: doi:10.1371/journal.pone.0094010
ISSN: 1932-6203
PURE UUID: 832f6f07-59f3-4ccb-981d-4c809d925dc8
ORCID for Hans Michael Haitchi: ORCID iD orcid.org/0000-0001-8603-302X
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248
ORCID for Donna E Davies: ORCID iD orcid.org/0000-0002-5117-2991

Catalogue record

Date deposited: 21 Sep 2015 10:34
Last modified: 15 Mar 2024 03:22

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Contributors

Author: Julie A. Cakebread
Author: Hans Michael Haitchi ORCID iD
Author: Yunhe Xu
Author: Stephen T Holgate
Author: Graham Roberts ORCID iD
Author: Donna E Davies ORCID iD

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