Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles

Parnia, Sam, Hamilton, Lynnsey M., Puddicombe, Sarah M., Holgate, Stephen T., Frew, A. and Davies, Donna E. (2014) Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles. Respiratory Research, 15, 22-32. (doi:10.1186/1465-9921-15-22). (PMID:24555532)

Record type: Article

Abstract

This study identifies a mechanism whereby diesel particles stimulates IL-8 release from bronchial epithelial cells. This mechanism may help to explain the recruitment of neutrophils into the airways of people exposed to particulate air pollution.

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Accepted/In Press date: 3 February 2014

Published date: 20 February 2014

Keywords: air pollution, neutrophilia, inflammation, epidermal growth factor receptor, interleukin-8, transactivation, ligand shedding

Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 380875

URI: http://eprints.soton.ac.uk/id/eprint/380875

DOI: doi:10.1186/1465-9921-15-22

ISSN: 1465-9921

PURE UUID: 33b8c527-c517-4055-a120-69c177df7a9d

ORCID for Donna E. Davies:

orcid.org/0000-0002-5117-2991

Catalogue record

Date deposited: 21 Sep 2015 10:40

Last modified: 15 Mar 2024 02:35

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Contributors

Author: Sam Parnia

Author: Lynnsey M. Hamilton

Author: Sarah M. Puddicombe

Author: Stephen T. Holgate

Author: A. Frew

Author: Donna E. Davies

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