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Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles
Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles
This study identifies a mechanism whereby diesel particles stimulates IL-8 release from bronchial epithelial cells. This mechanism may help to explain the recruitment of neutrophils into the airways of people exposed to particulate air pollution.
air pollution, neutrophilia, inflammation, epidermal growth factor receptor, interleukin-8, transactivation, ligand shedding
1465-9921
22-32
Parnia, Sam
74bcee7e-4e71-49e5-8a83-51d126c08d7c
Hamilton, Lynnsey M.
e013c481-745e-41fd-aa9e-ae02967fa44c
Puddicombe, Sarah M.
124e2c4e-ab9a-46f3-855c-b54ed0b61cc4
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Frew, A.
da440367-8ba9-4929-ba45-120bc5c8de0e
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38
Parnia, Sam
74bcee7e-4e71-49e5-8a83-51d126c08d7c
Hamilton, Lynnsey M.
e013c481-745e-41fd-aa9e-ae02967fa44c
Puddicombe, Sarah M.
124e2c4e-ab9a-46f3-855c-b54ed0b61cc4
Holgate, Stephen T.
2e7c17a9-6796-436e-8772-1fe6d2ac5edc
Frew, A.
da440367-8ba9-4929-ba45-120bc5c8de0e
Davies, Donna E.
7de8fdc7-3640-4e3a-aa91-d0e03f990c38

Parnia, Sam, Hamilton, Lynnsey M., Puddicombe, Sarah M., Holgate, Stephen T., Frew, A. and Davies, Donna E. (2014) Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles. Respiratory Research, 15, 22-32. (doi:10.1186/1465-9921-15-22). (PMID:24555532)

Record type: Article

Abstract

This study identifies a mechanism whereby diesel particles stimulates IL-8 release from bronchial epithelial cells. This mechanism may help to explain the recruitment of neutrophils into the airways of people exposed to particulate air pollution.

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Accepted/In Press date: 3 February 2014
Published date: 20 February 2014
Keywords: air pollution, neutrophilia, inflammation, epidermal growth factor receptor, interleukin-8, transactivation, ligand shedding
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 380875
URI: https://eprints.soton.ac.uk/id/eprint/380875
ISSN: 1465-9921
PURE UUID: 33b8c527-c517-4055-a120-69c177df7a9d
ORCID for Donna E. Davies: ORCID iD orcid.org/0000-0002-5117-2991

Catalogue record

Date deposited: 21 Sep 2015 10:40
Last modified: 15 Aug 2019 00:58

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Contributors

Author: Sam Parnia
Author: Lynnsey M. Hamilton
Author: Sarah M. Puddicombe
Author: A. Frew
Author: Donna E. Davies ORCID iD

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